| pubmed-article:17156454 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17156454 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:17156454 | lifeskim:mentions | umls-concept:C0599772 | lld:lifeskim |
| pubmed-article:17156454 | lifeskim:mentions | umls-concept:C0599044 | lld:lifeskim |
| pubmed-article:17156454 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:17156454 | lifeskim:mentions | umls-concept:C0079866 | lld:lifeskim |
| pubmed-article:17156454 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:17156454 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17156454 | pubmed:dateCreated | 2007-2-7 | lld:pubmed |
| pubmed-article:17156454 | pubmed:abstractText | We have established a reverse genetics approach for the routine generation of medaka (Oryzias latipes) gene knockouts. A cryopreserved library of N-ethyl-N-nitrosourea (ENU) mutagenized fish was screened by high-throughput resequencing for induced point mutations. Nonsense and splice site mutations were retrieved for the Blm, Sirt1, Parkin and p53 genes and functional characterization of p53 mutants indicated a complete knockout of p53 function. The current cryopreserved resource is expected to contain knockouts for most medaka genes. | lld:pubmed |
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| pubmed-article:17156454 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17156454 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17156454 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17156454 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17156454 | pubmed:issn | 1465-6914 | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:SakakiYoshiyu... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:ToyodaAtsushi... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:TodoTakeshiT | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:PlasterkRonal... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:YamazoeMitsuy... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:TakedaShunich... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:KondohHisatoH | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:TaniguchiYosh... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:MitaniHiroshi... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:Furutani-Seik... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:KameiYasuhiro... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:CuppenEdwinE | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:MuddeJosineJ | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:SasadoTakaoT | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:DeguchiTomono... | lld:pubmed |
| pubmed-article:17156454 | pubmed:author | pubmed-author:HidakaMasayuk... | lld:pubmed |
| pubmed-article:17156454 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17156454 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:17156454 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17156454 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17156454 | pubmed:pagination | R116 | lld:pubmed |
| pubmed-article:17156454 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:meshHeading | pubmed-meshheading:17156454... | lld:pubmed |
| pubmed-article:17156454 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17156454 | pubmed:articleTitle | Generation of medaka gene knockout models by target-selected mutagenesis. | lld:pubmed |
