| pubmed-article:1714485 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0206435 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C2003888 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0039476 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C1272755 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:1714485 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:1714485 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1714485 | pubmed:dateCreated | 1991-9-17 | lld:pubmed |
| pubmed-article:1714485 | pubmed:abstractText | Attenuated poliovirus strains induce less interferon-alpha (IFN-alpha) in human leukocyte cultures than their parental wild-type strains or other neurovirulent strains. We have used a set of type 3 Leon/Sabin recombinant poliovirus strains to show that production of IFN in this system is closely associated with the genomic region that codes for capsid protein VP3; a mutation in this gene also causes the temperature sensitivity of the attenuated Sabin 3 strain and is partly responsible for the loss of neurovirulence of this vaccine strain. Sixteen independent poliovirus isolates, derived from the Sabin 3 virus but showing in vitro and in vivo markers of neurovirulence, were also tested. These gave IFN yields equivalent to or higher than those obtained with the neurovirulent Leon type 3 poliovirus. The relatively low IFN yields with the Sabin 3 virus seem not to be a direct consequence of its temperature sensitivity, but the two properties coincide with all the type 3 poliovirus strains tested. | lld:pubmed |
| pubmed-article:1714485 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1714485 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1714485 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1714485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1714485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1714485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1714485 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1714485 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1714485 | pubmed:issn | 0197-8357 | lld:pubmed |
| pubmed-article:1714485 | pubmed:author | pubmed-author:HoviTT | lld:pubmed |
| pubmed-article:1714485 | pubmed:author | pubmed-author:MinotRR | lld:pubmed |
| pubmed-article:1714485 | pubmed:author | pubmed-author:AlmondJJ | lld:pubmed |
| pubmed-article:1714485 | pubmed:author | pubmed-author:PitkärantaAA | lld:pubmed |
| pubmed-article:1714485 | pubmed:author | pubmed-author:MacadamAA | lld:pubmed |
| pubmed-article:1714485 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1714485 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:1714485 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1714485 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1714485 | pubmed:pagination | 105-10 | lld:pubmed |
| pubmed-article:1714485 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:meshHeading | pubmed-meshheading:1714485-... | lld:pubmed |
| pubmed-article:1714485 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1714485 | pubmed:articleTitle | Covariance of lowered capacity to induce interferon in human leukocytes and temperature sensitivity of type 3 poliovirus. | lld:pubmed |
| pubmed-article:1714485 | pubmed:affiliation | Enterovirus Laboratory and Molecular Biology Unit, National Public Health Institute, Helsinki, Finland. | lld:pubmed |
| pubmed-article:1714485 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1714485 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1714485 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1714485 | lld:pubmed |
