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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0011065,
umls-concept:C0039194,
umls-concept:C0040300,
umls-concept:C0085358,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C1306235,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1704410,
umls-concept:C1704675,
umls-concept:C1706438,
umls-concept:C2698600,
umls-concept:C2728259
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pubmed:issue |
12
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pubmed:dateCreated |
2006-12-4
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pubmed:abstractText |
Constitutive presentation of tissue Ags by dendritic cells results in tolerance of autoreactive CD8+ T cells; however, the underlying molecular mechanisms are not well understood. In this study we show that programmed death (PD)-1, an inhibitory receptor of the CD28 family, is required for tolerance induction of autoreactive CD8+ T cells. An antagonistic Ab against PD-1 provoked destructive autoimmune diabetes in RIP-mOVA mice expressing chicken OVA in the pancreatic islet cells, which received naive OVA-specific CD8+ OT-I cells. This effect was mediated by the PD ligand (PD-L) PD-L1 but not by PD-L2. An increased number of effector OT-I cells recovered from the pancreatic lymph nodes of anti-PD-L1-treated mice showed down-regulation of PD-1. Furthermore, the blockade of PD-1/PD-L1 interaction during the priming phase did not significantly affect OT-I cell division but enhanced its granzyme B, IFN-gamma, and IL-2 production. Thus, during the presentation of tissue Ags to CD8+ T cells, PD-1/PD-L1 interaction crucially controls the effector differentiation of autoreactive T cells to maintain self-tolerance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cd274 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/PD-1 antigen, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8291-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17142723-Animals,
pubmed-meshheading:17142723-Antigen Presentation,
pubmed-meshheading:17142723-Antigens, CD274,
pubmed-meshheading:17142723-Antigens, CD80,
pubmed-meshheading:17142723-Antigens, Differentiation,
pubmed-meshheading:17142723-Apoptosis Regulatory Proteins,
pubmed-meshheading:17142723-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17142723-Chickens,
pubmed-meshheading:17142723-Dendritic Cells,
pubmed-meshheading:17142723-Diabetes Mellitus, Experimental,
pubmed-meshheading:17142723-Insulin-Secreting Cells,
pubmed-meshheading:17142723-Membrane Glycoproteins,
pubmed-meshheading:17142723-Mice,
pubmed-meshheading:17142723-Mice, Inbred C57BL,
pubmed-meshheading:17142723-Mice, Transgenic,
pubmed-meshheading:17142723-Ovalbumin,
pubmed-meshheading:17142723-Peptides,
pubmed-meshheading:17142723-Self Tolerance
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pubmed:year |
2006
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pubmed:articleTitle |
Cutting Edge: Programmed death (PD) ligand-1/PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens.
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pubmed:affiliation |
University of Texas M.D. Anderson Cancer Center, 7455 Fannin, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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