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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009247,
umls-concept:C0030705,
umls-concept:C0036983,
umls-concept:C0175630,
umls-concept:C0205419,
umls-concept:C0376515,
umls-concept:C0456603,
umls-concept:C0574032,
umls-concept:C0806987,
umls-concept:C1170000,
umls-concept:C1332397,
umls-concept:C1879547,
umls-concept:C2003941
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
2007-1-1
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|
pubmed:abstractText |
Drotrecogin alpha (activated) (DAA), or recombinant human activated protein C, is a new treatment in sepsis-induced multiple organ failure, leading to significant reduction in the mortality rate, thanks to its anticoagulant properties. It has been suggested that DAA has anti-inflammatory and antiapoptotic effects in sepsis animal models. This study investigates the potential actions of DAA on circulating mononuclear cells apoptosis in human septic shock.
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pubmed:language |
eng
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|
pubmed:journal |
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pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0090-3493
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
35
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-75
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pubmed:meshHeading |
pubmed-meshheading:17133181-Adult,
pubmed-meshheading:17133181-Aged,
pubmed-meshheading:17133181-Aged, 80 and over,
pubmed-meshheading:17133181-Analysis of Variance,
pubmed-meshheading:17133181-Anti-Infective Agents,
pubmed-meshheading:17133181-Apoptosis,
pubmed-meshheading:17133181-Female,
pubmed-meshheading:17133181-Flow Cytometry,
pubmed-meshheading:17133181-Gene Expression,
pubmed-meshheading:17133181-Humans,
pubmed-meshheading:17133181-Infusions, Intravenous,
pubmed-meshheading:17133181-Leukocyte Count,
pubmed-meshheading:17133181-Leukocytes, Mononuclear,
pubmed-meshheading:17133181-Lod Score,
pubmed-meshheading:17133181-Male,
pubmed-meshheading:17133181-Middle Aged,
pubmed-meshheading:17133181-Prospective Studies,
pubmed-meshheading:17133181-Protein C,
pubmed-meshheading:17133181-Recombinant Proteins,
pubmed-meshheading:17133181-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17133181-Shock, Septic,
pubmed-meshheading:17133181-bcl-2-Associated X Protein,
pubmed-meshheading:17133181-bcl-X Protein
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: a cohort study in septic shock patients.
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|
pubmed:affiliation |
Service de Réanimation Médicale, Hôpitaux Universitaires, and School of Medicine, University L. Pasteur, Strasbourg, France. pascal.bilbault@chru-strasbourg.fr
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
