| pubmed-article:1711294 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C0549193 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C2000948 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C2000949 | lld:lifeskim |
| pubmed-article:1711294 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1711294 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1711294 | pubmed:dateCreated | 1991-7-25 | lld:pubmed |
| pubmed-article:1711294 | pubmed:abstractText | The major objectives of this study were twofold: to determine 1) if growth factors or growth factor receptors were expressed similarly or differently in a clinically well-characterized group of breast cancer patients and 2) if these phenotypic characteristics were associated with any of the commonly used prognostic parameters. Formalin-fixed paraffin-embedded tumor tissue from 51 node-positive breast cancer patients were analyzed for the expression of neu, epidermal growth factor-receptor (EGF-R), and transforming growth factor alpha (TGF alpha) using immunoperoxidase staining. Positive membranous staining for neu was observed in 15 (29%) tumors. Over-expression of neu was observed in high-grade, estrogen-receptor-negative tumors (P less than 0.05). Epidermal growth factor receptor was expressed in 22 (43%) of the tumors analyzed and found to a greater degree in estrogen-receptor-negative and high-grade tumors (P less than 0.025). A significant correlation between neu and EGF-R expression was also noted. Tumors expressing membranous staining of neu had a greater than 70% chance of expressing EGF-R (P less than 0.01). Expression of TGF alpha was found in 68% of tumors and TGF alpha was detected in grade 1 and 2 tumor to a greater degree than EGF-R. The authors conclude that assaying tumors for these antigens may give additional phenotypic characteristics that can give further insight into the biology of breast cancer. | lld:pubmed |
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| pubmed-article:1711294 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1711294 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1711294 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1711294 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1711294 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1711294 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:1711294 | pubmed:author | pubmed-author:KramerSS | lld:pubmed |
| pubmed-article:1711294 | pubmed:author | pubmed-author:LundyJJ | lld:pubmed |
| pubmed-article:1711294 | pubmed:author | pubmed-author:SorvilloJ MJM | lld:pubmed |
| pubmed-article:1711294 | pubmed:author | pubmed-author:McCormackE... | lld:pubmed |
| pubmed-article:1711294 | pubmed:author | pubmed-author:SchussAA | lld:pubmed |
| pubmed-article:1711294 | pubmed:author | pubmed-author:StanickDD | lld:pubmed |
| pubmed-article:1711294 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1711294 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:1711294 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1711294 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1711294 | pubmed:pagination | 1527-34 | lld:pubmed |
| pubmed-article:1711294 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
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| pubmed-article:1711294 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1711294 | pubmed:articleTitle | Expression of neu protein, epidermal growth factor receptor, and transforming growth factor alpha in breast cancer. Correlation with clinicopathologic parameters. | lld:pubmed |
| pubmed-article:1711294 | pubmed:affiliation | Department of Pathology, Winthrop University Hospital, Mineola, New York. | lld:pubmed |
| pubmed-article:1711294 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1711294 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1711294 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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