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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-7-25
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pubmed:abstractText |
The major objectives of this study were twofold: to determine 1) if growth factors or growth factor receptors were expressed similarly or differently in a clinically well-characterized group of breast cancer patients and 2) if these phenotypic characteristics were associated with any of the commonly used prognostic parameters. Formalin-fixed paraffin-embedded tumor tissue from 51 node-positive breast cancer patients were analyzed for the expression of neu, epidermal growth factor-receptor (EGF-R), and transforming growth factor alpha (TGF alpha) using immunoperoxidase staining. Positive membranous staining for neu was observed in 15 (29%) tumors. Over-expression of neu was observed in high-grade, estrogen-receptor-negative tumors (P less than 0.05). Epidermal growth factor receptor was expressed in 22 (43%) of the tumors analyzed and found to a greater degree in estrogen-receptor-negative and high-grade tumors (P less than 0.025). A significant correlation between neu and EGF-R expression was also noted. Tumors expressing membranous staining of neu had a greater than 70% chance of expressing EGF-R (P less than 0.01). Expression of TGF alpha was found in 68% of tumors and TGF alpha was detected in grade 1 and 2 tumor to a greater degree than EGF-R. The authors conclude that assaying tumors for these antigens may give additional phenotypic characteristics that can give further insight into the biology of breast cancer.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-1690379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-173455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-17782530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2470152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2555057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2564806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2569032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2857419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2880347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2893663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2903446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-2999195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3002608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3003577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3007185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3013348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3044605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3047554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3365571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3474361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3664511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-3798106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-4151463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-6091821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-6095109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-6166661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-6320011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1711294-6331648
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1527-34
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:1711294-Adult,
pubmed-meshheading:1711294-Aged,
pubmed-meshheading:1711294-Aged, 80 and over,
pubmed-meshheading:1711294-Antibodies, Monoclonal,
pubmed-meshheading:1711294-Breast Neoplasms,
pubmed-meshheading:1711294-Female,
pubmed-meshheading:1711294-Humans,
pubmed-meshheading:1711294-Immunoenzyme Techniques,
pubmed-meshheading:1711294-Lymph Nodes,
pubmed-meshheading:1711294-Middle Aged,
pubmed-meshheading:1711294-Neoplasm Invasiveness,
pubmed-meshheading:1711294-Proto-Oncogene Proteins,
pubmed-meshheading:1711294-Receptor, Epidermal Growth Factor,
pubmed-meshheading:1711294-Receptor, erbB-2,
pubmed-meshheading:1711294-Staining and Labeling,
pubmed-meshheading:1711294-Transforming Growth Factor alpha,
pubmed-meshheading:1711294-Tumor Markers, Biological
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pubmed:year |
1991
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pubmed:articleTitle |
Expression of neu protein, epidermal growth factor receptor, and transforming growth factor alpha in breast cancer. Correlation with clinicopathologic parameters.
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pubmed:affiliation |
Department of Pathology, Winthrop University Hospital, Mineola, New York.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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