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rdf:type |
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lifeskim:mentions |
umls-concept:C0037083,
umls-concept:C0054950,
umls-concept:C0348011,
umls-concept:C0856825,
umls-concept:C1456796,
umls-concept:C1511545,
umls-concept:C1705822,
umls-concept:C1705984,
umls-concept:C1708528,
umls-concept:C1710082,
umls-concept:C2698594
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pubmed:issue |
5
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pubmed:dateCreated |
2007-2-21
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pubmed:abstractText |
Murine CD4+CD25+ regulatory T cells (Treg cells) reduce acute graft-versus-host disease (aGvHD). However, surface molecules critical for suppression are unclear. Deficiency of CD30 (CD30-/-) leads to impaired thymic negative selection and augmented T-cell autoreactivity. Therefore, we investigated the role of CD30 signaling in Treg-cell function during aGvHD. Treg cells derived from CD30-/- animals were significantly less effective in preventing aGvHD lethality. Early blockade of the CD30/CD153 pathway with a neutralizing anti-CD153 mAb reduced Treg-mediated protection from proinflammatory cytokine accumulation and donor-type T-cell apoptosis. In vivo bioluminescence imaging demonstrated intact homing but reduced expansion of luciferase-expressing Treg cells when CD153 was blocked during the early phase after adoptive transfer. CD30 surface expression on Treg cells increased with alloantigen exposure, and CD153 expression on recipient-type dendritic cells increased in the presence of a proinflammatory environment. These data demonstrate that early CD30 signaling is critical for Treg-mediated aGvHD protection after major MHC-mismatch bone marrow transplantation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-10384116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-10651989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-10754341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-10888927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-10899917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-11046041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-11086050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-11535631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-11869690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-11986199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-12163567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-12626551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-12720217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-12857946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-12925844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-14660744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-14688412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-14722622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-15322151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-15485635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-15546950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-15699103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-15778343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-15855275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-16002422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-16121185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-16294223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-16418326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-16522809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-16724101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-1994250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-7499966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-8391931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-8543792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-8568238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-8598042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-8871664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-9129201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-9403725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-9558389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-9670041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17068147-9826579
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2225-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17068147-Animals,
pubmed-meshheading:17068147-Mice,
pubmed-meshheading:17068147-Bone Marrow Transplantation,
pubmed-meshheading:17068147-Acute Disease,
pubmed-meshheading:17068147-Time Factors,
pubmed-meshheading:17068147-Isoantigens,
pubmed-meshheading:17068147-Graft vs Host Disease,
pubmed-meshheading:17068147-Adoptive Transfer,
pubmed-meshheading:17068147-Signal Transduction,
pubmed-meshheading:17068147-T-Lymphocytes, Regulatory
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