|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010654,
umls-concept:C0025663,
umls-concept:C0034760,
umls-concept:C0205314,
umls-concept:C0441633,
umls-concept:C0596902,
umls-concept:C0599682,
umls-concept:C0679622,
umls-concept:C0814423,
umls-concept:C1873171,
umls-concept:C2603343
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2006-11-20
|
|
pubmed:abstractText |
A novel substituted cysteine accessibility method (SCAM) reagent was developed for monoamine uptake transporters. The new reagent, MTS-MPP(+), was a derivative of the neurotoxin and transporter substrate MPP(+). MTS-MPP(+) labeled cysteine residues introduced into the serotonin transporter protein. Although it did not prove to be a substrate, as is MPP(+), it appears to label cysteine residues lining the permeation pore of the transporter more readily than currently available nonspecific SCAM reagents.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-11015197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-11591153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-11665562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-12657510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-15164608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-16041361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-6251863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-7718244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-8161456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-8204619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-8609898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-8968583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-9063896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17064910-9779459
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0968-0896
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
305-11
|
|
pubmed:dateRevised |
2011-9-26
|
|
pubmed:meshHeading |
pubmed-meshheading:17064910-Cell Line,
pubmed-meshheading:17064910-Cysteine,
pubmed-meshheading:17064910-Humans,
pubmed-meshheading:17064910-Iodides,
pubmed-meshheading:17064910-Models, Molecular,
pubmed-meshheading:17064910-Molecular Structure,
pubmed-meshheading:17064910-Pyridinium Compounds,
pubmed-meshheading:17064910-Serotonin,
pubmed-meshheading:17064910-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:17064910-Structure-Activity Relationship
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47906, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
