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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-11-14
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pubmed:abstractText |
Overexpression and/or activity of c-Src non-receptor tyrosine kinase is associated with progression of several human epithelial cancers including breast cancer. c-Src activity in 'pure' ductal carcinoma in situ (DCIS) was measured to assess whether this predicts recurrence and/or correlates with HER2 expression and other clinical parameters. Activated c-Src levels were evaluated in DCIS biopsies from 129 women, with median follow-up at 60 months. High levels of activated c-Src correlated with HER2 positivity, high tumour grade, comedo necrosis and elevated epithelial proliferation. In univariate analysis, high activated c-Src level associated with lower recurrence-free survival at 5 years (P=0.011). Thus, high c-Src activity may identify a subset of DCIS with high risk of recurrence or progression to invasive cancer where therapeutics targeting c-Src may benefit this patient subset.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-10411101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-10430251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-11114744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-11313890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-11821453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-12020799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-12462387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-12941830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-1380891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-14735188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-14996930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-15170449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-15669025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-15753384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-15788662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-16360410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-16397019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-16412380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-3798106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-6403227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-7507074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-7879656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-7903421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-8621432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-9014858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17060931-9735325
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1410-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17060931-Breast Neoplasms,
pubmed-meshheading:17060931-Carcinoma, Ductal, Breast,
pubmed-meshheading:17060931-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:17060931-Cell Proliferation,
pubmed-meshheading:17060931-Disease-Free Survival,
pubmed-meshheading:17060931-Female,
pubmed-meshheading:17060931-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17060931-Humans,
pubmed-meshheading:17060931-Immunoenzyme Techniques,
pubmed-meshheading:17060931-Middle Aged,
pubmed-meshheading:17060931-Neoplasm Recurrence, Local,
pubmed-meshheading:17060931-Neoplasm Staging,
pubmed-meshheading:17060931-Predictive Value of Tests,
pubmed-meshheading:17060931-Proto-Oncogene Proteins pp60(c-src),
pubmed-meshheading:17060931-Receptor, erbB-2,
pubmed-meshheading:17060931-Tumor Markers, Biological
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pubmed:year |
2006
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pubmed:articleTitle |
Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity.
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pubmed:affiliation |
Department of Academic Surgery, Research and Education Building 2nd Floor, South Manchester University Hospital, Wythenshawe, Manchester, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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