Source:http://linkedlifedata.com/resource/pubmed/id/17047971
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-11-22
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pubmed:abstractText |
Granulocyte-colony stimulating factor (G-CSF) receptor signaling counteracts detrimental pathways in ischemic stroke. In rodents, neuroprotection provided by the G-CSF system involves up-regulation of the G-CSF receptor and its ligand, G-CSF, during cerebral ischemia. The confirmation of a similar response in the human brain would be an important rationale for the use of G-CSF in clinical stroke trials. Therefore, the temporal and cellular profile of G-CSF and G-CSF receptor expression was examined in a series of human stroke brains. The median age of the 21 stroke patients was 67 years; median time from death to autopsy was 24 h (range: 10-67 h). In acute ischemic stroke, strong neuronal G-CSF receptor immunoreactivity was encountered in the infarct area and the peri-infarct rim as compared to the contralateral cortex. In subacute infarctions, microglial and macrophage G-CSF receptor immunoreactivity predominated, whereas chronic infarction was characterized by the presence of G-CSF receptor expressing reactive astrocytes. Neuronal G-CSF expression was encountered very early upon ischemic stroke. At later time-points, an up-regulation of vascular G-CSF expression in the peri-infarct area prevailed. In conclusion, the observed up-regulation of G-CSF receptors and G-CSF points towards a role in the pathophysiology of human ischemic stroke.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0001-6322
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-51
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17047971-Aged,
pubmed-meshheading:17047971-Aged, 80 and over,
pubmed-meshheading:17047971-Autopsy,
pubmed-meshheading:17047971-Female,
pubmed-meshheading:17047971-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:17047971-Humans,
pubmed-meshheading:17047971-Male,
pubmed-meshheading:17047971-Middle Aged,
pubmed-meshheading:17047971-Postmortem Changes,
pubmed-meshheading:17047971-Receptors, Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:17047971-Stroke,
pubmed-meshheading:17047971-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Granulocyte-colony stimulating factor (G-CSF) and G-CSF receptor expression in human ischemic stroke.
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pubmed:affiliation |
Institute of Neuropathology, University Hospital Münster, Domagkstr. 19, 48129, Münster, Germany. hasselblatt@uni-muenster.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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