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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-10-16
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pubmed:abstractText |
The CCND1 gene generates two mRNAs (cyclin D1a and D1b) through an alternative splicing at the site of a common A/G polymorphism. Cyclin D1a and b proteins differ in their C-terminus, a region involved in protein degradation and sub-cellular localization. Recent data have suggested that cyclin D1b could be a nuclear oncogene. The presence of cyclin D1b mRNA and protein has been studied in two hemopathies in which cyclin D1 could be present: multiple myeloma (MM) and mantle cell lymphoma (MCL). The A/G polymorphism of CCND1 has also been verified in a series of patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-10929713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-11418364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-12620412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-12646964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-12746453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-1386335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-14612495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-15551329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-15755896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-15951302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-16247460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-16321849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-16550162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-7675441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-9372967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-9591636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17022831-9832503
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
238
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17022831-Cell Line, Tumor,
pubmed-meshheading:17022831-Cyclin D,
pubmed-meshheading:17022831-Cyclins,
pubmed-meshheading:17022831-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17022831-Humans,
pubmed-meshheading:17022831-Lymphoma, Mantle-Cell,
pubmed-meshheading:17022831-Multiple Myeloma,
pubmed-meshheading:17022831-Polymorphism, Genetic,
pubmed-meshheading:17022831-RNA, Messenger
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pubmed:year |
2006
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pubmed:articleTitle |
Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphoma.
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pubmed:affiliation |
Laboratoire de Biologie Moléculaire et Cellulaire de la Signalisation, EA 3919, Université de Caen, France. s.krieger@baclesse.fr
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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