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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
27
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pubmed:dateCreated |
2006-9-19
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pubmed:abstractText |
To improve prognosis in children with acute myeloid leukemia (AML) by randomized comparisons of (1) two short consolidation cycles versus the Berlin-Frankfurt-Muenster (BFM) -type biphasic 6-week consolidation and (2) the prophylactic administration of granulocyte colony-stimulating factor (G-CSF) versus no G-CSF. Further, therapy for standard risk patients was intensified by addition of a second induction, HAM (high-dose cytarabine and mitoxantrone).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:CreutzigUrsulaU,
pubmed-author:DworzakMichaelM,
pubmed-author:GrafNorbertN,
pubmed-author:HermannJohannJ,
pubmed-author:LehrnbecherThomasT,
pubmed-author:NiemeyerCharlotte MCM,
pubmed-author:ReinhardtDirkD,
pubmed-author:ReiterAlfredA,
pubmed-author:RitterJörgJ,
pubmed-author:StittE SES,
pubmed-author:ZimmermannMartinM
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4499-506
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16983120-Acute Disease,
pubmed-meshheading:16983120-Adolescent,
pubmed-meshheading:16983120-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16983120-Child,
pubmed-meshheading:16983120-Child, Preschool,
pubmed-meshheading:16983120-Cranial Irradiation,
pubmed-meshheading:16983120-Cytarabine,
pubmed-meshheading:16983120-Daunorubicin,
pubmed-meshheading:16983120-Disease-Free Survival,
pubmed-meshheading:16983120-Drug Administration Schedule,
pubmed-meshheading:16983120-Female,
pubmed-meshheading:16983120-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:16983120-Humans,
pubmed-meshheading:16983120-Idarubicin,
pubmed-meshheading:16983120-Infant,
pubmed-meshheading:16983120-Infection,
pubmed-meshheading:16983120-Leukemia, Myeloid,
pubmed-meshheading:16983120-Male,
pubmed-meshheading:16983120-Mitoxantrone,
pubmed-meshheading:16983120-Neutropenia,
pubmed-meshheading:16983120-Radiotherapy, Adjuvant,
pubmed-meshheading:16983120-Risk Assessment,
pubmed-meshheading:16983120-Risk Factors,
pubmed-meshheading:16983120-Survival Analysis,
pubmed-meshheading:16983120-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
Less toxicity by optimizing chemotherapy, but not by addition of granulocyte colony-stimulating factor in children and adolescents with acute myeloid leukemia: results of AML-BFM 98.
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pubmed:affiliation |
Department of Hematology/Oncology, University Children's Hospital, Muenster, Germany. ursula@creutzig.de
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase III
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