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pubmed-article:16968794pubmed:abstractTextActivation-induced cell death (AICD) is a major mechanism in the regulation of peripheral tolerance, and caspase-3 represents its major executioner. AICD impairment contributes to the persistence of autoreactive T cells, and defective AICD has been reported in autoimmune thyroiditis as well as in type 1 diabetes mellitus.lld:pubmed
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pubmed-article:16968794pubmed:articleTitleImpaired caspase-3 expression by peripheral T cells in chronic autoimmune thyroiditis and in autoimmune polyendocrine syndrome-2.lld:pubmed
pubmed-article:16968794pubmed:affiliationDiabetes Unit, Department of Internal Medicine, University of Siena, Siena, Italy.lld:pubmed
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