Linked Life Data

1696730

Source:http://linkedlifedata.com/resource/pubmed/id/1696730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1990-9-20
pubmed:abstractText
The mammalian intestinal epithelium undergoes continuous and rapid renewal of its four principal terminally differentiated cell types. These cells arise from multipotent stem cells located at or near the base of the crypts of Lieberkühn. The differentiation process is precisely organized along two spatial dimensions (axes)--from the crypt to the villus tip and from the duodenum to the colon. The enteroendocrine cell population provides a sensitive marker of the intestine's topologic differentiation. At least 15 different regionally distributed subsets have been described based on their principal neuroendocrine products. We have used immunocytochemical methods to characterize the spatial relationships of the serotonin-, secretin-, and substance P-containing enteroendocrine cell subsets in normal adult C57BL/6J x LT/Sv mice as well as in transgenic littermates that contain rat liver fatty acid-binding protein-human growth hormone fusion genes. Our results reveal precise spatial interrelationships between these populations and suggest a differentiation pathway that may involve the sequential expression of substance P, serotonin, and secretin.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-1095530, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-114241, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2186049, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2415956, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2417286, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2462524, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2470367, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2472998, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2647764, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-2768279, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-3510411, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-3967298, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-3974703, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-4216261, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-4440635, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-6194039, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-6204735, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-6207221, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-632061, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-6349575, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-6869670, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-76465, http://linkedlifedata.com/resource/pubmed/commentcorrection/1696730-791906
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/FABP7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Fabp5 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Secretin, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin, http://linkedlifedata.com/resource/pubmed/chemical/Substance P, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6408-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:1696730-Animals, pubmed-meshheading:1696730-Carrier Proteins, pubmed-meshheading:1696730-Epithelial Cells, pubmed-meshheading:1696730-Fatty Acid-Binding Proteins, pubmed-meshheading:1696730-Fluorescent Antibody Technique, pubmed-meshheading:1696730-Growth Hormone, pubmed-meshheading:1696730-Humans, pubmed-meshheading:1696730-Intestine, Small, pubmed-meshheading:1696730-Liver, pubmed-meshheading:1696730-Mice, pubmed-meshheading:1696730-Mice, Inbred C57BL, pubmed-meshheading:1696730-Mice, Transgenic, pubmed-meshheading:1696730-Microvilli, pubmed-meshheading:1696730-Muscle, Smooth, pubmed-meshheading:1696730-Neoplasm Proteins, pubmed-meshheading:1696730-Nerve Tissue Proteins, pubmed-meshheading:1696730-Rats, pubmed-meshheading:1696730-Recombinant Fusion Proteins, pubmed-meshheading:1696730-Secretin, pubmed-meshheading:1696730-Serotonin, pubmed-meshheading:1696730-Substance P, pubmed-meshheading:1696730-Tumor Suppressor Proteins
pubmed:year
1990
pubmed:articleTitle
Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice.
pubmed:affiliation
Department of Pathology, Washington University School of Medicine, Saint Louis, MO 63110.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't