Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-11-23
pubmed:abstractText
A major model system for the study of evolutionary divergence between closely related species has been the unisexual lethality resulting from reciprocal crosses of Drosophila melanogaster and D. simulans. Sex-lethal (Sxl), a critical gene for sex determination, is misregulated in these hybrids. In hybrid males from D. melanogaster mothers, there is an abnormal expression of Sxl and a failure of localization of the male-specific lethal (MSL) complex to the X chromosome, which causes changes in gene expression. Introduction of a Sxl mutation into this hybrid genotype will allow expression of the MSL complex but there is no sequestration to the X chromosome. Lethal hybrid rescue (Lhr), which allows hybrid males from this cross to survive, corrects the SXL and MSL defects. The reciprocal cross of D. simulans mothers by D. melanogaster males exhibits underexpression of Sxl in embryos.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-10224258, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-10445035, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-105964, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-10679323, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-10747067, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-10835396, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-10980435, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-11396999, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-11867536, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-11882543, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-12663535, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-12695567, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-12723697, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-12752761, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-12777520, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-12802326, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-1305123, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-14962989, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-15564384, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-15716510, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-15797617, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-16234327, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-16543150, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-1900493, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-2108905, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-2503427, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-3000609, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-3108667, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-3144435, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-7402300, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8005444, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8170369, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8224857, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8355601, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8370520, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8436276, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8436277, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-8635465, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-9038336, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-9038337, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-9144292, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-9155031, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951071-9182767
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
174
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1151-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids.
pubmed:affiliation
Division of Biological Sciences, University of Missouri, Columbia 65211-7400, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural