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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-9-1
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pubmed:abstractText |
The inflammatory response that is directed in large part by proinflammatory cytokine interleukin (IL)-1 is genetically determined, with some people having a more vigorous response than others to the same stimulus. The reason for this is speculated that the dysregulated production of IL-1 in some individuals overrides the feedback mechanisms that normally master the dose of inflammation to a level sufficient to fight microbial invasion without long-lasting damage to the tissues involved. The aims of the present study were to determine the distribution of IL-1 gene polymorphism (IL-1A+4845 and IL-1B+3954) and their association with periodontal disease severity and to determine the significance of detecting the composite genotype (IL-1A allele2+IL-1B allele2) versus detecting either of them alone.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3492
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1515-21
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16945028-Alleles,
pubmed-meshheading:16945028-Case-Control Studies,
pubmed-meshheading:16945028-Chi-Square Distribution,
pubmed-meshheading:16945028-Chronic Disease,
pubmed-meshheading:16945028-Female,
pubmed-meshheading:16945028-Gene Frequency,
pubmed-meshheading:16945028-Genetic Predisposition to Disease,
pubmed-meshheading:16945028-Genotype,
pubmed-meshheading:16945028-Humans,
pubmed-meshheading:16945028-India,
pubmed-meshheading:16945028-Interleukin-1,
pubmed-meshheading:16945028-Male,
pubmed-meshheading:16945028-Molecular Epidemiology,
pubmed-meshheading:16945028-Odds Ratio,
pubmed-meshheading:16945028-Periodontal Attachment Loss,
pubmed-meshheading:16945028-Periodontal Index,
pubmed-meshheading:16945028-Periodontitis,
pubmed-meshheading:16945028-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:16945028-Polymorphism, Single Nucleotide,
pubmed-meshheading:16945028-Statistics, Nonparametric,
pubmed-meshheading:16945028-Tooth Mobility
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pubmed:year |
2006
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pubmed:articleTitle |
Assessment of single nucleotide polymorphism at IL-1A+4845 and IL-1B+3954 as genetic susceptibility test for chronic periodontitis in Maharashtrian ethnicity.
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pubmed:affiliation |
Department of Periodontics, Government Dental College and Hospital, Gandhi Medical College, Nagpur, Maharashtra, India.
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pubmed:publicationType |
Journal Article
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