|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0001962,
umls-concept:C0006104,
umls-concept:C0007367,
umls-concept:C0035820,
umls-concept:C0047640,
umls-concept:C0162772,
umls-concept:C0183683,
umls-concept:C0205178,
umls-concept:C0237638,
umls-concept:C0344211,
umls-concept:C1171411,
umls-concept:C1280500,
umls-concept:C1317973,
umls-concept:C1511253,
umls-concept:C1521721,
umls-concept:C1704245,
umls-concept:C1704351,
umls-concept:C1704445,
umls-concept:C1948023
|
|
pubmed:issue |
7-8
|
|
pubmed:dateCreated |
2006-11-19
|
|
pubmed:abstractText |
The antioxidant enzyme catalase by reacting with H(2)O(2), forms the compound known as compound I (catalase-H(2)O(2)). This compound is able to oxidise ethanol to acetaldehyde in the CNS. It has been demonstrated that 3-nitropropionic acid (3-NPA) induces the activity of the brain catalase-H(2)O(2) system. In this study, we tested the effect of 3-NPA on both the brain catalase-H(2)O(2) system and on the acute locomotor effect of ethanol. To find the optimal interval for the 3-NPA-ethanol interaction mice were treated with 3-NPA 0, 45, 90 and 135min before an ethanol injection (2.4mg/kg). In a second study, 3-NPA (0, 15, 30 or 45mg/kg) was administered SC to animals 90min before saline or several doses of ethanol (1.6 or 2.4g/kg), and the open-field behaviour was registered. The specificity of the effect of 3-NPA (45mg/kg) was evaluated on caffeine (10mg/kg IP) and cocaine (4mg/kg)-induced locomotion. The prevention of 3-NPA effects on both ethanol-induced locomotion and brain catalase activity by L-carnitine, a potent antioxidant, was also studied. Nitropropionic acid boosted ethanol-induced locomotion and brain catalase activity after 90min. The effect of 3-NPA was prevented by l-carnitine administration. These results indicate that 3-NPA enhanced ethanol-induced locomotion by increasing the activity of the brain catalase system.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitropropionic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Acetaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Amitrole,
http://linkedlifedata.com/resource/pubmed/chemical/Caffeine,
http://linkedlifedata.com/resource/pubmed/chemical/Carnitine,
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Propionic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0028-3908
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1137-45
|
|
pubmed:meshHeading |
pubmed-meshheading:16938317-Acetaldehyde,
pubmed-meshheading:16938317-Amitrole,
pubmed-meshheading:16938317-Animals,
pubmed-meshheading:16938317-Brain Chemistry,
pubmed-meshheading:16938317-Caffeine,
pubmed-meshheading:16938317-Carnitine,
pubmed-meshheading:16938317-Catalase,
pubmed-meshheading:16938317-Drug Synergism,
pubmed-meshheading:16938317-Energy Metabolism,
pubmed-meshheading:16938317-Ethanol,
pubmed-meshheading:16938317-Hydrogen Peroxide,
pubmed-meshheading:16938317-Locomotion,
pubmed-meshheading:16938317-Male,
pubmed-meshheading:16938317-Mice,
pubmed-meshheading:16938317-Models, Neurological,
pubmed-meshheading:16938317-Motor Activity,
pubmed-meshheading:16938317-Nitro Compounds,
pubmed-meshheading:16938317-Oxidants,
pubmed-meshheading:16938317-Oxidation-Reduction,
pubmed-meshheading:16938317-Propionic Acids,
pubmed-meshheading:16938317-Reactive Oxygen Species,
pubmed-meshheading:16938317-Receptors, N-Methyl-D-Aspartate
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Acute administration of 3-nitropropionic acid, a reactive oxygen species generator, boosts ethanol-induced locomotor stimulation. New support for the role of brain catalase in the behavioural effects of ethanol.
|
|
pubmed:affiliation |
Area de Psicobiologia, Universitat Jaume I, Castelló, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
