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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-3-29
|
| pubmed:abstractText |
In this paper we report the development of the immunologically detected uncoupling protein (UCP) in brown adipose tissue during the perinatal period in the rat and its relationship with its functional activity expressed in terms of GDP-binding capacity, GDP-sensitive permeabilities and GDP-sensitive respiration. Immunologically detected UCP increased during the last 2 days of foetal life (under euthermic conditions) and after birth (after postnatal hypothermia) during the early suckling period, reaching its maximum value on day 10 after birth. This increase in UCP is accompanied by parallel increases in the GDP-binding capacity, GDP-sensitive permeabilities to protons and chloride ions and GDP-inhibitable respiration. During the suckling--weaning transition, there was a regression of the parameters related to the functional activity of the UCP (GDP-binding capacity and nucleotide-sensitive permeabilities and respiration) without changes in the immunologically detected UCP. These results suggest that the involution of this tissue in the rat commences in this period; the first parameters affected are those related to the functional activity of the UCP while the UCP is still present in its highest level. This seems to support the idea that, in this period of development of the rat, the UCP may exist in the brown fat mitochondria in a functional (unmasked) form and a non-functional (masked) form.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protons,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-2956
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
14
|
| pubmed:volume |
187
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
671-5
|
| pubmed:dateRevised |
2007-7-23
|
| pubmed:meshHeading |
pubmed-meshheading:1689244-Adipose Tissue, Brown,
pubmed-meshheading:1689244-Animals,
pubmed-meshheading:1689244-Animals, Suckling,
pubmed-meshheading:1689244-Blotting, Western,
pubmed-meshheading:1689244-Body Temperature Regulation,
pubmed-meshheading:1689244-Carrier Proteins,
pubmed-meshheading:1689244-Chlorides,
pubmed-meshheading:1689244-GTP-Binding Proteins,
pubmed-meshheading:1689244-Guanosine Diphosphate,
pubmed-meshheading:1689244-Intracellular Membranes,
pubmed-meshheading:1689244-Ion Channels,
pubmed-meshheading:1689244-Membrane Proteins,
pubmed-meshheading:1689244-Mitochondria,
pubmed-meshheading:1689244-Mitochondrial Proteins,
pubmed-meshheading:1689244-Oxygen Consumption,
pubmed-meshheading:1689244-Protons,
pubmed-meshheading:1689244-Rats,
pubmed-meshheading:1689244-Rats, Inbred Strains
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Development of the uncoupling protein in the rat brown-adipose tissue during the perinatal period. Its relationship with the mitochondrial GDP-binding and GDP-sensitive ion permeabilities and respiration.
|
| pubmed:affiliation |
Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|