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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-8-1
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pubmed:abstractText |
To investigate the role of the leader sequence (which during clusterin biosynthesis facilitates its proper post-translational processing and secretion) in the functional activities of clusterin, a ubiquitous secretory glycoprotein with many biological functions, reported to be pro-apoptotic and anti-apoptotic in target cells, but for which the dual mechanism remains unclear.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-4096
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pubmed:author |
pubmed-author:GuoYingluY,
pubmed-author:JangThomas LTL,
pubmed-author:JovanovicBorkoB,
pubmed-author:KunduShilajitS,
pubmed-author:LeeChungC,
pubmed-author:LiangLiliL,
pubmed-author:PinsMichaelM,
pubmed-author:SmithNormN,
pubmed-author:XinDianqiD,
pubmed-author:YangXimingX,
pubmed-author:ZhangQiangQ,
pubmed-author:ZhouWeiW
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
452-60
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16879694-Apoptosis,
pubmed-meshheading:16879694-Clusterin,
pubmed-meshheading:16879694-DNA, Complementary,
pubmed-meshheading:16879694-Disease Progression,
pubmed-meshheading:16879694-Humans,
pubmed-meshheading:16879694-Immunohistochemistry,
pubmed-meshheading:16879694-Male,
pubmed-meshheading:16879694-Polymerase Chain Reaction,
pubmed-meshheading:16879694-Prostatic Neoplasms,
pubmed-meshheading:16879694-Protein Sorting Signals,
pubmed-meshheading:16879694-Tumor Cells, Cultured
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pubmed:year |
2006
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pubmed:articleTitle |
The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro.
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pubmed:affiliation |
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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