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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-7-31
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pubmed:abstractText |
Natural killer (NK) cells play a key role in inflammation and tumor regression through their ability to migrate into tissues. CXCL12 is a chemokine that promotes lymphocyte invasion and migration into tissues; however, the mechanism for this process remains incompletely understood. In this study, we show that CXCL12 significantly enhanced CD16(+)CD56(+) human peripheral NK-cell invasion into type I collagen by the catalytic activity of matrix metalloproteinase-1 (MMP-1). Confocal immunofluorescence and co-immunoprecipitation studies suggest that MMP-1 colocalized with alpha(2)beta(1) integrin on CXCL-12-stimulated NK-cell surface. The binding of pro-MMP-1 with alpha(2)beta(1) integrin required activation of G(i)-coupled pathway. However, the production of MMP-1 from CXCL12-stimulated NK cells was mediated by p38 and mitogen-activated or extracellular signal-regulation protein kinase kinase 1/2 in a manner independent of the G(i)-coupled pathway. These results suggest that CXCL12/CXCR4 interaction transduces the two signaling pathways to promote NK-cell invasion, which stimulates pericellular degradation of extracellular matrix proteins by membrane-associated MMP-1. The mechanisms would thus play a role in facilitating lymphocyte trafficking and accumulation in tissues during physiological and pathological processes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10222060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10419448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10506573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10740253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10754298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10820269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10852105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10912795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-10970876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11063876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11110686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11154210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11156241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11207257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11254681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11278606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11359786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11359797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11369622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11497249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11544020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-11688724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12149192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12209631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12225788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12421931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12601028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12706853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12730128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12824186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-12865405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-14962105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-15027120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-15100278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-15225625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-15843590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-2164689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-2822727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-3257251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-8134392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-8629022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-8752280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-8752281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-9064327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-9240423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16877347-9574526
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha2beta1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9440
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pubmed:author |
pubmed-author:DomaeNaochikaN,
pubmed-author:GodaSeijiS,
pubmed-author:HarakawaNariN,
pubmed-author:IidaJojiJ,
pubmed-author:IkeoTakashiT,
pubmed-author:ImaiHisaoH,
pubmed-author:InoueHiroshiH,
pubmed-author:LeePeterP,
pubmed-author:MacarthyJames BJB,
pubmed-author:MiyajiMichihikoM,
pubmed-author:NaganoYutakaY,
pubmed-author:ShimizuYojiY,
pubmed-author:UmeharaHisanoriH
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pubmed:issnType |
Print
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
445-58
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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