Source:http://linkedlifedata.com/resource/pubmed/id/16876806
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2006-10-18
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pubmed:abstractText |
In micro total analysis systems, liquid chromatography (LC) works under pressure-driven flow is the essential analysis component. There were not, however, much works on microchip LC. Here we developed a microchip for reversed-phase LC using porous monolithic silica. The chip consisted of a double T-shaped injector and a approximately 40-cm serpentine separation channel. The octadecyl-modified monolithic silica was prepared in the specified part of the channel on the microchip using sol-gel process. Furthermore, the effect of geometry of turn sections on band dispersion at turns was examined under pressure-driven flow. High separation efficiencies of 15,000-18,000 plates/m for catechins were obtained using the LC chip.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9673
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
1132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90-8
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pubmed:dateRevised |
2009-1-15
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pubmed:meshHeading | |
pubmed:year |
2006
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pubmed:articleTitle |
Reversed-phase liquid chromatography on a microchip with sample injector and monolithic silica column.
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pubmed:affiliation |
Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Nishi 8, Kita 13, Sapporo 060-8628, Japan. ishida-a@eng.hokudai.ac.jp <ishida-a@eng.hokudai.ac.jp>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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