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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
31
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pubmed:dateCreated |
2006-8-2
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pubmed:abstractText |
Conditional N-Myc deletion limits the proliferation of granule neuron progenitors (GNPs), perturbs foliation, and leads to reduced cerebellar mass. We show that c-Myc mRNA levels increase in N-Myc-null GNPs and that simultaneous deletion of both c- and N-Myc exacerbates defective cerebellar development. Moreover, N-Myc loss has been shown to trigger the precocious expression of two cyclin-dependent kinase inhibitors, Kip1 and Ink4c, in the cerebellar primordium. We now further demonstrate that the engineered disruption of the Kip1 and Ink4c genes in N-Myc-null cerebella partially rescues GNP cell proliferation and cerebellar foliation. These results provide definitive genetic evidence that expression of N-Myc and concomitant down-regulation of Ink4c and Kip1 contribute to the proper development of the cerebellum.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-10880462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-10908616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-10918589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-11163229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-11433373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-11511533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-11684436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-11742404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-11922389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-12215636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-12381668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-12502747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-12529648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-14473282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-14500378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-1459449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-14999071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-15229481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-15723053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-15723054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-16064138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-16260494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-16724113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-2785918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-3215042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-3382957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-8646779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-8646780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-8646781,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-9735945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16864777-9744866
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11579-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16864777-Animals,
pubmed-meshheading:16864777-Cell Proliferation,
pubmed-meshheading:16864777-Cerebellum,
pubmed-meshheading:16864777-Cyclin-Dependent Kinase Inhibitor p18,
pubmed-meshheading:16864777-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:16864777-Gene Expression Regulation, Developmental,
pubmed-meshheading:16864777-Mice,
pubmed-meshheading:16864777-Mice, Knockout,
pubmed-meshheading:16864777-Mice, Transgenic,
pubmed-meshheading:16864777-Proto-Oncogene Proteins c-myc
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pubmed:year |
2006
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pubmed:articleTitle |
N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development.
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pubmed:affiliation |
Department of Genetics and Tumor Cell Biology, Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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