| pubmed-article:16860583 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16860583 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:16860583 | lifeskim:mentions | umls-concept:C0020615 | lld:lifeskim |
| pubmed-article:16860583 | lifeskim:mentions | umls-concept:C0021666 | lld:lifeskim |
| pubmed-article:16860583 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:16860583 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:16860583 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16860583 | pubmed:dateCreated | 2006-9-4 | lld:pubmed |
| pubmed-article:16860583 | pubmed:abstractText | In some patients with non-islet-cell tumor hypoglycemia (NICTH), a high molecular weight form of IGF-II (big IGF-II) derived from tumors is present in the circulation and might be associated with recurrent hypoglycemia. In this study, in order to survey the clinical characteristics of patients with IGF-II producing NICTH, we analyzed the medical records of 78 patients with NICTH (M/F 44/34, age 62+/-1.8, range; 9-86 years.) whose serum contained a large amount of big IGF-II. Hepatocellular carcinoma and gastric carcinoma were the most common causes of NICTH. The diameters of the tumors were more than 10 cm in 70% of the patients. Basal immunoreactive insulin (IRI) levels were less than 3 microU/dl in 79% of the patients. Hypoglycemic attack was the onset of disease in 31 of 65 cases (48%), but the tumor was revealed prior to the occurrence of hypoglycemia in 34 cases (52%). Twenty-five of 47 (53%) patients had decreased serum potassium levels. These data suggested that hypoinsulinemic hypoglycemia associated with the presence of a large tumor supports the diagnosis of IGF-II producing NICTH. Hypokalemia was associated with hypoglycemia in some patients. The BMI (21.4+/-0.6 kg/m2) and serum total protein levels (6.6+/-0.1g/dl) were preserved at the occurrence of first hypoglycemic attack suggesting that malnutrition might not be the main cause of hypoglycemia in most patients. | lld:pubmed |
| pubmed-article:16860583 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16860583 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16860583 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16860583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16860583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16860583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16860583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16860583 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16860583 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16860583 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16860583 | pubmed:issn | 1096-6374 | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:MurakamiYukoY | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:MoritaJunkoJ | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:TakanoKazueK | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:FukudaIzumiI | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:HizukaNaomiN | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:YasumotoKumik... | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:IshikawaYukik... | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:SataAkiraA | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:OkuboYumikoY | lld:pubmed |
| pubmed-article:16860583 | pubmed:author | pubmed-author:KurimotoMakik... | lld:pubmed |
| pubmed-article:16860583 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16860583 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:16860583 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16860583 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16860583 | pubmed:pagination | 211-6 | lld:pubmed |
| pubmed-article:16860583 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16860583 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16860583 | pubmed:articleTitle | Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia. | lld:pubmed |
| pubmed-article:16860583 | pubmed:affiliation | Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, Tokyo, Japan. | lld:pubmed |
| pubmed-article:16860583 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16860583 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16860583 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16860583 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16860583 | lld:pubmed |
