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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-9-4
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pubmed:abstractText |
In some patients with non-islet-cell tumor hypoglycemia (NICTH), a high molecular weight form of IGF-II (big IGF-II) derived from tumors is present in the circulation and might be associated with recurrent hypoglycemia. In this study, in order to survey the clinical characteristics of patients with IGF-II producing NICTH, we analyzed the medical records of 78 patients with NICTH (M/F 44/34, age 62+/-1.8, range; 9-86 years.) whose serum contained a large amount of big IGF-II. Hepatocellular carcinoma and gastric carcinoma were the most common causes of NICTH. The diameters of the tumors were more than 10 cm in 70% of the patients. Basal immunoreactive insulin (IRI) levels were less than 3 microU/dl in 79% of the patients. Hypoglycemic attack was the onset of disease in 31 of 65 cases (48%), but the tumor was revealed prior to the occurrence of hypoglycemia in 34 cases (52%). Twenty-five of 47 (53%) patients had decreased serum potassium levels. These data suggested that hypoinsulinemic hypoglycemia associated with the presence of a large tumor supports the diagnosis of IGF-II producing NICTH. Hypokalemia was associated with hypoglycemia in some patients. The BMI (21.4+/-0.6 kg/m2) and serum total protein levels (6.6+/-0.1g/dl) were preserved at the occurrence of first hypoglycemic attack suggesting that malnutrition might not be the main cause of hypoglycemia in most patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1096-6374
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16860583-Adolescent,
pubmed-meshheading:16860583-Adrenal Gland Neoplasms,
pubmed-meshheading:16860583-Adult,
pubmed-meshheading:16860583-Aged,
pubmed-meshheading:16860583-Aged, 80 and over,
pubmed-meshheading:16860583-Blood Glucose,
pubmed-meshheading:16860583-Breast Neoplasms,
pubmed-meshheading:16860583-Carcinoma, Hepatocellular,
pubmed-meshheading:16860583-Carcinoma, Renal Cell,
pubmed-meshheading:16860583-Child,
pubmed-meshheading:16860583-Female,
pubmed-meshheading:16860583-Fibrosarcoma,
pubmed-meshheading:16860583-Gastrointestinal Stromal Tumors,
pubmed-meshheading:16860583-Humans,
pubmed-meshheading:16860583-Hypoglycemia,
pubmed-meshheading:16860583-Insulin-Like Growth Factor I,
pubmed-meshheading:16860583-Insulin-Like Growth Factor II,
pubmed-meshheading:16860583-Leiomyosarcoma,
pubmed-meshheading:16860583-Liver Neoplasms,
pubmed-meshheading:16860583-Male,
pubmed-meshheading:16860583-Middle Aged,
pubmed-meshheading:16860583-Neoplasms,
pubmed-meshheading:16860583-Pancreatic Neoplasms,
pubmed-meshheading:16860583-Pheochromocytoma,
pubmed-meshheading:16860583-Prostatic Neoplasms,
pubmed-meshheading:16860583-Proteins,
pubmed-meshheading:16860583-Retrospective Studies,
pubmed-meshheading:16860583-Stomach Neoplasms
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pubmed:year |
2006
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pubmed:articleTitle |
Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia.
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pubmed:affiliation |
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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