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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-9-18
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pubmed:abstractText |
Neuregulin-1 (NRG-1) is an active component found in sciatic nerve conditioned medium (CM). NRG-1 is a growth and differentiation factor shown to have an effect on neuritogenesis and survival of neural cells. PC12 cells chronically treated with NRG-1 (beta1 isoform) show an increase in proliferation under low-serum condition (2.5% fetal bovine serum and 1.25% horse serum) and serum deprivation, without visible morphological changes. NRG-1 and CM treatments of PC12 cells induced an increase of voltage-activated Ca2+ currents and large-conductance calcium-activated K+ currents (KCa). AG825, a specific inhibitor for erbB2 receptor, abolishes KCa current, though Ca2+ currents were not inhibited. These results showed that NRG-1 is capable of inducing functional changes but is not sufficient on its own to have an effect on cell morphology.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzothiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Charybdotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Serum-Free,
http://linkedlifedata.com/resource/pubmed/chemical/Erbb2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Iodobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Neuregulin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins,
http://linkedlifedata.com/resource/pubmed/chemical/o-iodoxybenzoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/tyrphostin AG825
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
1110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
64-75
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16859657-Analysis of Variance,
pubmed-meshheading:16859657-Animals,
pubmed-meshheading:16859657-Benzothiazoles,
pubmed-meshheading:16859657-Calcium Channels,
pubmed-meshheading:16859657-Cell Differentiation,
pubmed-meshheading:16859657-Cell Proliferation,
pubmed-meshheading:16859657-Charybdotoxin,
pubmed-meshheading:16859657-Culture Media, Conditioned,
pubmed-meshheading:16859657-Culture Media, Serum-Free,
pubmed-meshheading:16859657-Dose-Response Relationship, Drug,
pubmed-meshheading:16859657-Drug Interactions,
pubmed-meshheading:16859657-Electric Stimulation,
pubmed-meshheading:16859657-Glycoproteins,
pubmed-meshheading:16859657-Humans,
pubmed-meshheading:16859657-Iodobenzenes,
pubmed-meshheading:16859657-Neuregulin-1,
pubmed-meshheading:16859657-Neurotoxins,
pubmed-meshheading:16859657-PC12 Cells,
pubmed-meshheading:16859657-Patch-Clamp Techniques,
pubmed-meshheading:16859657-Potassium Channels, Calcium-Activated,
pubmed-meshheading:16859657-Protein Isoforms,
pubmed-meshheading:16859657-Rats,
pubmed-meshheading:16859657-Receptor, erbB-2,
pubmed-meshheading:16859657-Sciatic Nerve,
pubmed-meshheading:16859657-Tyrphostins
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pubmed:year |
2006
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pubmed:articleTitle |
Neuregulin-1 isoform induces mitogenesis, KCa and Ca2+ currents in PC12 cells. A comparison with sciatic nerve conditioned medium.
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pubmed:affiliation |
Centro de Biociencias y Medicina Molecular, Instituto de Estudios Avanzados-IDEA, Apartado 17606, Caracas, Venezuela. ccastill@reacciun.ve
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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