| pubmed-article:16855620 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C0072978 | lld:lifeskim |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16855620 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:16855620 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:16855620 | pubmed:dateCreated | 2006-10-25 | lld:pubmed |
| pubmed-article:16855620 | pubmed:abstractText | RANTES (regulated on activation, normal T-cell expressed and secreted) is a T-helper type 1 (Th1) chemokine that promotes T-cell activation and proliferation. RANTES is genetically associated with asthma, sarcoidosis and multiple sclerosis. The concentration of RANTES is increased at inflammation sites in different autoimmune diseases. Type 1 diabetes (T1D) is a Th1-mediated disease with complex genetic predisposition. We tested RANTES as a candidate gene for association with T1D using three single-nucleotide polymorphism (SNP) variants (rs4251719, rs2306630 and rs2107538) to capture haplotype information. The minor alleles of all SNPs were transmitted less frequently to T1D offspring (transmission rates 37.3% (P=0.002), 38.7% (P=0.007) and 41.0% (P=0.01)) and were less frequently present in patients compared to controls (P=0.009, 0.03 and 0.04, respectively). A similar protective effect was observed for the haplotype carrying three minor alleles (transmission disequilibrium test (TDT): P=0.003; odds ratio (OR)=0.55; confidence interval (CI): 0.37-0.83; case/control: P=0.03; OR=0.74; CI: 0.55-0.98). Both patients and controls carrying the protective haplotype express significantly lower serum levels of RANTES compared to non-carriers. Subsequently, we tested a cohort of 310 celiac disease patients, but failed to detect association. RANTES SNPs are significantly associated with RANTES serum concentration and development of T1D. The rs4251719*A-rs2306630*A-rs2107538*A haplotype associated with low RANTES production confers protection from T1D. Our data imply that RANTES is associated with T1D both genetically and functionally, and contributes to diabetes-prone Th1 cytokine profile. | lld:pubmed |
| pubmed-article:16855620 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16855620 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16855620 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16855620 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16855620 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16855620 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16855620 | pubmed:issn | 1466-4879 | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:WijmengaCC | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:RoepB OBO | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:SchlootN CNC | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:Hanifi-Moghad... | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:AlizadehB ZBZ | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:EerlighPP | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:KoelemanB P... | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:DiosdadoBB | lld:pubmed |
| pubmed-article:16855620 | pubmed:author | pubmed-author:ZhernakovaAA | lld:pubmed |
| pubmed-article:16855620 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16855620 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:16855620 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16855620 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16855620 | pubmed:pagination | 544-9 | lld:pubmed |
| pubmed-article:16855620 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16855620 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16855620 | pubmed:articleTitle | Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. | lld:pubmed |
| pubmed-article:16855620 | pubmed:affiliation | Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:16855620 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16855620 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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