Source:http://linkedlifedata.com/resource/pubmed/id/16855620
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2006-10-25
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| pubmed:abstractText |
RANTES (regulated on activation, normal T-cell expressed and secreted) is a T-helper type 1 (Th1) chemokine that promotes T-cell activation and proliferation. RANTES is genetically associated with asthma, sarcoidosis and multiple sclerosis. The concentration of RANTES is increased at inflammation sites in different autoimmune diseases. Type 1 diabetes (T1D) is a Th1-mediated disease with complex genetic predisposition. We tested RANTES as a candidate gene for association with T1D using three single-nucleotide polymorphism (SNP) variants (rs4251719, rs2306630 and rs2107538) to capture haplotype information. The minor alleles of all SNPs were transmitted less frequently to T1D offspring (transmission rates 37.3% (P=0.002), 38.7% (P=0.007) and 41.0% (P=0.01)) and were less frequently present in patients compared to controls (P=0.009, 0.03 and 0.04, respectively). A similar protective effect was observed for the haplotype carrying three minor alleles (transmission disequilibrium test (TDT): P=0.003; odds ratio (OR)=0.55; confidence interval (CI): 0.37-0.83; case/control: P=0.03; OR=0.74; CI: 0.55-0.98). Both patients and controls carrying the protective haplotype express significantly lower serum levels of RANTES compared to non-carriers. Subsequently, we tested a cohort of 310 celiac disease patients, but failed to detect association. RANTES SNPs are significantly associated with RANTES serum concentration and development of T1D. The rs4251719*A-rs2306630*A-rs2107538*A haplotype associated with low RANTES production confers protection from T1D. Our data imply that RANTES is associated with T1D both genetically and functionally, and contributes to diabetes-prone Th1 cytokine profile.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1466-4879
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
544-9
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16855620-Adolescent,
pubmed-meshheading:16855620-Adult,
pubmed-meshheading:16855620-Aged,
pubmed-meshheading:16855620-Aged, 80 and over,
pubmed-meshheading:16855620-Alleles,
pubmed-meshheading:16855620-Case-Control Studies,
pubmed-meshheading:16855620-Celiac Disease,
pubmed-meshheading:16855620-Chemokine CCL5,
pubmed-meshheading:16855620-Child,
pubmed-meshheading:16855620-Child, Preschool,
pubmed-meshheading:16855620-Cohort Studies,
pubmed-meshheading:16855620-Diabetes Mellitus, Type 1,
pubmed-meshheading:16855620-Female,
pubmed-meshheading:16855620-Gene Frequency,
pubmed-meshheading:16855620-Genetic Variation,
pubmed-meshheading:16855620-Haplotypes,
pubmed-meshheading:16855620-Humans,
pubmed-meshheading:16855620-Infant,
pubmed-meshheading:16855620-Male,
pubmed-meshheading:16855620-Middle Aged,
pubmed-meshheading:16855620-Polymorphism, Single Nucleotide
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes.
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| pubmed:affiliation |
Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|