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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-7-14
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pubmed:abstractText |
We previously detected a promoter polymorphism (- 109C/T) in the gene for the beta-chain of the high-affinity receptor for IgE (FCER1B), which was associated with total serum IgE levels but not with asthma in a Japanese population. A genetic interaction is biologically plausible between FcepsilonRI-beta and the plasminogen activator inhibitor 1 (PAI-1), which is highly expressed in mast cells in asthmatics and plays an essential role in airway remodelling. We hypothesized that FCER1B promoter polymorphisms, by modifying the intensity of mast cell activation signals, modulate the genetic effects of a functional 4G/5G polymorphism in the PAI-1 gene on asthma. OBJECTICIVE: To examine whether FCER1B promoter polymorphisms (- 109C/T and - 654C/T) influence the genetic effects of the functional polymorphism (4G/5G) at the PAI-1 promoter region on asthma susceptibility using a case-control analysis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0954-7894
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
872-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16839401-Adolescent,
pubmed-meshheading:16839401-Adult,
pubmed-meshheading:16839401-Aged,
pubmed-meshheading:16839401-Aged, 80 and over,
pubmed-meshheading:16839401-Asthma,
pubmed-meshheading:16839401-Case-Control Studies,
pubmed-meshheading:16839401-Female,
pubmed-meshheading:16839401-Gene Frequency,
pubmed-meshheading:16839401-Genetic Predisposition to Disease,
pubmed-meshheading:16839401-Genetic Variation,
pubmed-meshheading:16839401-Genotype,
pubmed-meshheading:16839401-Humans,
pubmed-meshheading:16839401-Male,
pubmed-meshheading:16839401-Middle Aged,
pubmed-meshheading:16839401-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:16839401-Polymorphism, Genetic,
pubmed-meshheading:16839401-Promoter Regions, Genetic,
pubmed-meshheading:16839401-Receptors, IgE
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pubmed:year |
2006
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pubmed:articleTitle |
Genetic polymorphisms at FCER1B and PAI-1 and asthma susceptibility.
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pubmed:affiliation |
First Department of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. nhizawa@med.hokudai.ac.jp
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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