Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-8-28
pubmed:abstractText
The effect of hyperbaric oxygenation (HBO2) was investigated in a rat model of indomethacin-induced enteropathy. Enteropathy was induced by two subcutaneous injections of indomethacin (7.5 mg/kg) 24 hr apart. Six groups of rats (n=8) were treated with and without HBO2 (100% oxygen at 2.3 atm absolute) for 1 hr once or twice a day for 2 or 5 days. Disease activity index (DAI) and total ulcer length were measured. Other rats were randomized into two groups (n=16) with and without HBO2 (1 hr once a day) and four rats were killed in each group at 12, 24, 48, and 72 hr after the final injection of indomethacin. Serum and intestinal mucosal TNF-alpha, IL-1beta, myeloperoxidase (MPO), and iNOS expression was measured. HBO2 treatment significantly attenuated indomethacin -induced intestinal ulceration and improved DAI. Indomethacin increased MPO activity and iNOS expression, and these were reduced by HBO2 treatment, with a concomitant reduction in TNF-alpha and IL-1beta. Our data suggest that HBO2 treatment has a beneficial effect on indomethacin-induced enteropathy and this effect is possibly mediated by decreased production of TNF-alpha and IL-1beta.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0163-2116
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1426-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16838118-Animals, pubmed-meshheading:16838118-Biological Markers, pubmed-meshheading:16838118-Disease Models, Animal, pubmed-meshheading:16838118-Disease Progression, pubmed-meshheading:16838118-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:16838118-Hyperbaric Oxygenation, pubmed-meshheading:16838118-Indomethacin, pubmed-meshheading:16838118-Interleukin-1, pubmed-meshheading:16838118-Intestinal Diseases, pubmed-meshheading:16838118-Intestinal Mucosa, pubmed-meshheading:16838118-Male, pubmed-meshheading:16838118-Nitric Oxide Synthase Type II, pubmed-meshheading:16838118-Peroxidase, pubmed-meshheading:16838118-Rats, pubmed-meshheading:16838118-Rats, Sprague-Dawley, pubmed-meshheading:16838118-Severity of Illness Index, pubmed-meshheading:16838118-Treatment Outcome, pubmed-meshheading:16838118-Tumor Necrosis Factor-alpha, pubmed-meshheading:16838118-Ulcer
pubmed:year
2006
pubmed:articleTitle
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
pubmed:affiliation
Research Laboratory, Department of Anesthesiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA. yangz@upstate.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't