Source:http://linkedlifedata.com/resource/pubmed/id/16838118
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2006-8-28
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pubmed:abstractText |
The effect of hyperbaric oxygenation (HBO2) was investigated in a rat model of indomethacin-induced enteropathy. Enteropathy was induced by two subcutaneous injections of indomethacin (7.5 mg/kg) 24 hr apart. Six groups of rats (n=8) were treated with and without HBO2 (100% oxygen at 2.3 atm absolute) for 1 hr once or twice a day for 2 or 5 days. Disease activity index (DAI) and total ulcer length were measured. Other rats were randomized into two groups (n=16) with and without HBO2 (1 hr once a day) and four rats were killed in each group at 12, 24, 48, and 72 hr after the final injection of indomethacin. Serum and intestinal mucosal TNF-alpha, IL-1beta, myeloperoxidase (MPO), and iNOS expression was measured. HBO2 treatment significantly attenuated indomethacin -induced intestinal ulceration and improved DAI. Indomethacin increased MPO activity and iNOS expression, and these were reduced by HBO2 treatment, with a concomitant reduction in TNF-alpha and IL-1beta. Our data suggest that HBO2 treatment has a beneficial effect on indomethacin-induced enteropathy and this effect is possibly mediated by decreased production of TNF-alpha and IL-1beta.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0163-2116
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1426-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16838118-Animals,
pubmed-meshheading:16838118-Biological Markers,
pubmed-meshheading:16838118-Disease Models, Animal,
pubmed-meshheading:16838118-Disease Progression,
pubmed-meshheading:16838118-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:16838118-Hyperbaric Oxygenation,
pubmed-meshheading:16838118-Indomethacin,
pubmed-meshheading:16838118-Interleukin-1,
pubmed-meshheading:16838118-Intestinal Diseases,
pubmed-meshheading:16838118-Intestinal Mucosa,
pubmed-meshheading:16838118-Male,
pubmed-meshheading:16838118-Nitric Oxide Synthase Type II,
pubmed-meshheading:16838118-Peroxidase,
pubmed-meshheading:16838118-Rats,
pubmed-meshheading:16838118-Rats, Sprague-Dawley,
pubmed-meshheading:16838118-Severity of Illness Index,
pubmed-meshheading:16838118-Treatment Outcome,
pubmed-meshheading:16838118-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16838118-Ulcer
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pubmed:year |
2006
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pubmed:articleTitle |
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
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pubmed:affiliation |
Research Laboratory, Department of Anesthesiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA. yangz@upstate.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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