Linked Life Data

16817862

Source:http://linkedlifedata.com/resource/pubmed/id/16817862

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2006-7-4
pubmed:abstractText
Transient cerebral ischemia causes an inhomogeneous pattern of cell death in the brain. We investigated mechanisms, which may underlie the greater susceptibility of hippocampal CA1 vs. CA3 pyramidal cells to ischemic insult. Using an in vitro oxygen-glucose deprivation (OGD) model of ischemia, we found that N-methyl-D-aspartate (NMDA) responses were enhanced in the more susceptible CA1 pyramidal cells and transiently depressed in the resistant CA3 pyramidal cells. The long-lasting potentiation of NMDA responses in CA1 cells was associated with delayed cell death and was prevented by blocking tyrosine kinase-dependent up-regulation of NMDA receptor function. In CA3 cells, the energy deprivation-induced transient depression of NMDA responses was converted to potentiation by blocking protein phosphatase signalling. These results suggest that energy deprivation differentially shifts the intracellular equilibrium between the tyrosine kinase and phosphatase activities that modulate NMDA responses in CA1 and CA3 pyramidal cells. Therapeutic modulation of tyrosine phosphorylation may thus prove beneficial in mitigating ischemia-induced neuronal death in vulnerable brain areas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2595-603
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16817862-Animals, pubmed-meshheading:16817862-Cell Death, pubmed-meshheading:16817862-Enzyme Activation, pubmed-meshheading:16817862-Enzyme Inhibitors, pubmed-meshheading:16817862-Excitatory Amino Acid Antagonists, pubmed-meshheading:16817862-Hippocampus, pubmed-meshheading:16817862-Hypoxia-Ischemia, Brain, pubmed-meshheading:16817862-Immunohistochemistry, pubmed-meshheading:16817862-Long-Term Potentiation, pubmed-meshheading:16817862-Organ Culture Techniques, pubmed-meshheading:16817862-Patch-Clamp Techniques, pubmed-meshheading:16817862-Phosphoric Monoester Hydrolases, pubmed-meshheading:16817862-Protein-Tyrosine Kinases, pubmed-meshheading:16817862-Pyramidal Cells, pubmed-meshheading:16817862-Rats, pubmed-meshheading:16817862-Rats, Wistar, pubmed-meshheading:16817862-Receptors, N-Methyl-D-Aspartate
pubmed:year
2006
pubmed:articleTitle
NMDA receptors and the differential ischemic vulnerability of hippocampal neurons.
pubmed:affiliation
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. geec@access.unizh.ch
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't