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rdf:type |
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lifeskim:mentions |
umls-concept:C0001271,
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0059239,
umls-concept:C0185117,
umls-concept:C0599894,
umls-concept:C1099354,
umls-concept:C1366765,
umls-concept:C1366894,
umls-concept:C1518174,
umls-concept:C1521840,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2239176,
umls-concept:C2599702,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2007-2-19
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pubmed:abstractText |
HAb18G/CD147 has been identified as a factor that induces MMPs production. SiRNA targeted against HAb18G/CD147 was transfected into FHCC-98 cells (a HCC cell line) to knockdown its expression. The results showed that downregulating HAb18G/CD147 decreased ERK1/2, MMP-2 and FAK levels and inhibited cell motility and invasion, together with rearranged actin stress fiber formation, while had no effects on integrin alpha3beta1 expression. MEK1/2 inhibitor, U0126, inhibited MMP-2, FAK and actin expression in FHCC-98 cell line. The findings indicate that si-HAb18G inhibits gelatinase production, actin and FAK expression in FHCC-98 via an ERK1/2 signaling pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD147,
http://linkedlifedata.com/resource/pubmed/chemical/BSG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
247
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
336-44
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16815629-Actins,
pubmed-meshheading:16815629-Antigens, CD147,
pubmed-meshheading:16815629-Base Sequence,
pubmed-meshheading:16815629-Carcinoma, Hepatocellular,
pubmed-meshheading:16815629-Cell Line, Tumor,
pubmed-meshheading:16815629-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:16815629-Humans,
pubmed-meshheading:16815629-Liver Neoplasms,
pubmed-meshheading:16815629-Matrix Metalloproteinase 2,
pubmed-meshheading:16815629-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:16815629-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:16815629-RNA, Small Interfering
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pubmed:year |
2007
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pubmed:articleTitle |
siRNA targeted against HAb18G/CD147 inhibits MMP-2 secretion, actin and FAK expression in hepatocellular carcinoma cell line via ERK1/2 pathway.
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pubmed:affiliation |
Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, 17 West Changle Street, Xi'an, Shaanxi Province 710032, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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