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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-6-20
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pubmed:abstractText |
Activating mutations of either KIT or platelet-derived growth factor receptor alpha (PDGFRA) genes are present in the majority of gastrointestinal stromal tumours (GISTs). The type of gene mutation is associated with the aggressiveness of the disease, response to imatinib therapy, and the tumour site in the gastrointestinal tract. However, a subgroup of GISTs does not harbour these mutations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
805-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16785193-Adult,
pubmed-meshheading:16785193-Aged,
pubmed-meshheading:16785193-Aged, 80 and over,
pubmed-meshheading:16785193-Female,
pubmed-meshheading:16785193-Gastrointestinal Stromal Tumors,
pubmed-meshheading:16785193-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16785193-Humans,
pubmed-meshheading:16785193-Intestinal Neoplasms,
pubmed-meshheading:16785193-Male,
pubmed-meshheading:16785193-Middle Aged,
pubmed-meshheading:16785193-Mutation,
pubmed-meshheading:16785193-Peritoneal Neoplasms,
pubmed-meshheading:16785193-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:16785193-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:16785193-Stomach Neoplasms
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pubmed:year |
2006
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pubmed:articleTitle |
Platelet-derived growth factor receptor family mutations in gastrointestinal stromal tumours.
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pubmed:affiliation |
Laboratory of Molecular Oncology, Biomedicum, Haartmaninkatu 8, PO Box 700, FIN-00029 Helsinki, Finland. harri.sihto@helsinki.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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