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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-8-10
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pubmed:abstractText |
Elevated expression of cyclooxygenase-2 has been found in colorectal cancer. One of the mechanisms through which cyclooxygenase-2 affects tumorigenesis is through its overexpression, which leads to increased invasiveness of cancer cells. A crucial step in this pathway is thought to be the induction of membrane-type-1 matrix metalloproteinase, which activates matrix metalloproteinase-2. However, to date there have been few clinicopathologic studies concerning cyclooxygenase-2-mediated invasiveness in human colorectal cancer tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-3706
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pubmed:author |
pubmed-author:FujimoriShunjiS,
pubmed-author:FukudaYuhY,
pubmed-author:FurukawaKiyonoriK,
pubmed-author:GudisKatyaK,
pubmed-author:GuoHongfeiH,
pubmed-author:KishidaTeruyukiT,
pubmed-author:SakamotoChoitsuC,
pubmed-author:ShinjiSeiichiS,
pubmed-author:SugisakiYuichiY,
pubmed-author:TajiriTakashiT,
pubmed-author:TanakaShuS,
pubmed-author:TatsuguchiAtsushiA
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1184-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16752205-Adult,
pubmed-meshheading:16752205-Aged,
pubmed-meshheading:16752205-Aged, 80 and over,
pubmed-meshheading:16752205-Colorectal Neoplasms,
pubmed-meshheading:16752205-Cyclooxygenase 2,
pubmed-meshheading:16752205-Female,
pubmed-meshheading:16752205-Humans,
pubmed-meshheading:16752205-Immunoenzyme Techniques,
pubmed-meshheading:16752205-Male,
pubmed-meshheading:16752205-Matrix Metalloproteinase 1,
pubmed-meshheading:16752205-Matrix Metalloproteinase 2,
pubmed-meshheading:16752205-Matrix Metalloproteinases,
pubmed-meshheading:16752205-Middle Aged
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pubmed:year |
2006
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pubmed:articleTitle |
Cyclooxygenase-2 expression correlates with membrane-type-1 matrix metalloproteinase expression in colorectal cancer tissue.
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pubmed:affiliation |
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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