Linked Life Data

16681032

Source:http://linkedlifedata.com/resource/pubmed/id/16681032

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pubmed-article:16681032pubmed:abstractTextOchnaflavone is a medicinal herbal product isolated from Lonicera japonica that inhibits cyclooxygenase-2 (COX-2) dependent phases of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC50 values of 0.6 microM. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in quantity of the PGD2 product was accompanied by a decrease in the COX-2 protein level. In addition, this compound consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 6.56 microM. These results demonstrate that ochnaflavone has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity. Furthermore, this compound strongly inhibited degranulation reaction in a dose dependent manner, with an IC50 value of 3.01 microM. Therefore, this compound might provide a basis for novel anti-inflammatory drugs.lld:pubmed
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pubmed-article:16681032pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:16681032pubmed:year2006lld:pubmed
pubmed-article:16681032pubmed:articleTitleNaturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.lld:pubmed
pubmed-article:16681032pubmed:affiliationSkeletal Diseases Genome Research Center, Kyungpook National University, Daegu 702-701, Korea.lld:pubmed
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pubmed-article:16681032pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:16681032pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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