rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
2006-5-9
|
pubmed:abstractText |
Ochnaflavone is a medicinal herbal product isolated from Lonicera japonica that inhibits cyclooxygenase-2 (COX-2) dependent phases of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC50 values of 0.6 microM. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in quantity of the PGD2 product was accompanied by a decrease in the COX-2 protein level. In addition, this compound consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 6.56 microM. These results demonstrate that ochnaflavone has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity. Furthermore, this compound strongly inhibited degranulation reaction in a dose dependent manner, with an IC50 value of 3.01 microM. Therefore, this compound might provide a basis for novel anti-inflammatory drugs.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0253-6269
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
29
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
282-6
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:16681032-Animals,
pubmed-meshheading:16681032-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16681032-Arachidonate 5-Lipoxygenase,
pubmed-meshheading:16681032-Bone Marrow Cells,
pubmed-meshheading:16681032-Cell Degranulation,
pubmed-meshheading:16681032-Cyclooxygenase 2,
pubmed-meshheading:16681032-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:16681032-Dose-Response Relationship, Drug,
pubmed-meshheading:16681032-Flavonoids,
pubmed-meshheading:16681032-Leukotriene C4,
pubmed-meshheading:16681032-Lipoxygenase Inhibitors,
pubmed-meshheading:16681032-Lonicera,
pubmed-meshheading:16681032-Male,
pubmed-meshheading:16681032-Mast Cells,
pubmed-meshheading:16681032-Mice,
pubmed-meshheading:16681032-Mice, Inbred BALB C,
pubmed-meshheading:16681032-Prostaglandin D2
|
pubmed:year |
2006
|
pubmed:articleTitle |
Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
|
pubmed:affiliation |
Skeletal Diseases Genome Research Center, Kyungpook National University, Daegu 702-701, Korea.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|