| pubmed-article:16621960 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C0209338 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C0282625 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1291802 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:16621960 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:16621960 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16621960 | pubmed:dateCreated | 2006-8-7 | lld:pubmed |
| pubmed-article:16621960 | pubmed:abstractText | CCR5 is a receptor for several beta chemokines and the entry coreceptor used by macrophage-tropic (R5) strains of HIV-1. In addition to supporting viral entry, CCR5 ligation by the HIV-1 envelope glycoprotein 120 (gp120) can activate intracellular signals in macrophages and trigger inflammatory mediator release. Using a combination of in vitro kinase assay, Western blotting for phospho-specific proteins, pharmacologic inhibition, CCR5 knockout (CCR5Delta32) cells, and kinase-specific blocking peptide, we show for the first time that signaling through CCR5 in primary human macrophages is linked to the Src kinase Lyn. Stimulation of human monocyte-derived macrophages with either HIV-1 gp120 or MIP-1beta results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2. Furthermore, activation of the CCR5/Lyn/ERK-1/2 pathway is responsible for gp120-triggered production of TNF-alpha by macrophages, which is believed to contribute to HIV-1 pathogenesis. Thus, Lyn kinase may play an important role both in normal CCR5 function in macrophages and in AIDS pathogenesis in syndromes such as AIDS dementia where HIV-1 gp120 contributes to inappropriate macrophage activation, mediator production, and secondary injury. | lld:pubmed |
| pubmed-article:16621960 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16621960 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16621960 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16621960 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16621960 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:16621960 | pubmed:author | pubmed-author:CheungRickyR | lld:pubmed |
| pubmed-article:16621960 | pubmed:author | pubmed-author:TomkowiczBria... | lld:pubmed |
| pubmed-article:16621960 | pubmed:author | pubmed-author:CollmanRonald... | lld:pubmed |
| pubmed-article:16621960 | pubmed:author | pubmed-author:PtasznikAndrz... | lld:pubmed |
| pubmed-article:16621960 | pubmed:author | pubmed-author:LeeChuheeC | lld:pubmed |
| pubmed-article:16621960 | pubmed:author | pubmed-author:RavynVipaV | lld:pubmed |
| pubmed-article:16621960 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16621960 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:16621960 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:16621960 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16621960 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16621960 | pubmed:pagination | 1145-50 | lld:pubmed |
| pubmed-article:16621960 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:16621960 | pubmed:meshHeading | pubmed-meshheading:16621960... | lld:pubmed |
| pubmed-article:16621960 | pubmed:meshHeading | pubmed-meshheading:16621960... | lld:pubmed |
