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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7 Pt 1
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pubmed:dateCreated |
2006-4-12
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pubmed:abstractText |
Gastrin-releasing peptide (GRP) is a growth factor for small cell lung cancer (SCLC). GRP belongs to the bombesin peptide family and has significant homology to bombesin. We constructed a bispecific molecule, OKT3xAntag2, by conjugating a monoclonal antibody OKT3 (anti-CD3) with a bombesin/GRP antagonist (Antag2) and evaluated cytotoxicity against SCLC cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2224-31
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16609038-Animals,
pubmed-meshheading:16609038-Antibodies, Monoclonal,
pubmed-meshheading:16609038-Antineoplastic Agents,
pubmed-meshheading:16609038-Apoptosis,
pubmed-meshheading:16609038-Binding Sites,
pubmed-meshheading:16609038-Carcinoma, Small Cell,
pubmed-meshheading:16609038-Cell Line, Tumor,
pubmed-meshheading:16609038-Cell Proliferation,
pubmed-meshheading:16609038-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:16609038-Disease Models, Animal,
pubmed-meshheading:16609038-Humans,
pubmed-meshheading:16609038-Immunoconjugates,
pubmed-meshheading:16609038-Immunotherapy,
pubmed-meshheading:16609038-Interferon-gamma,
pubmed-meshheading:16609038-Lung Neoplasms,
pubmed-meshheading:16609038-Mice,
pubmed-meshheading:16609038-Mice, Inbred NOD,
pubmed-meshheading:16609038-Muromonab-CD3,
pubmed-meshheading:16609038-Oxytocin,
pubmed-meshheading:16609038-Receptors, Bombesin,
pubmed-meshheading:16609038-Structure-Activity Relationship,
pubmed-meshheading:16609038-T-Lymphocytes,
pubmed-meshheading:16609038-Transplantation, Heterologous,
pubmed-meshheading:16609038-Tumor Cells, Cultured,
pubmed-meshheading:16609038-Xenograft Model Antitumor Assays
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pubmed:year |
2006
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pubmed:articleTitle |
Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes.
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pubmed:affiliation |
Division of Blood and Marrow Transplantation, Department of Medicine and Moores University of California at San Diego Cancer Center, University of California San Diego, La Jolla, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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