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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-5-25
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pubmed:abstractText |
It has been proposed that serotonin (5-HT)-mediated constriction of the murine trachea is largely dependent on acetylcholine (ACh) released from the epithelium. We recently demonstrated that ACh can be released from non-neuronal cells by corticosteroid-sensitive polyspecific organic cation transporters (OCTs), which are also expressed by airway epithelial cells. Hence, the hypothesis emerged that 5-HT evokes bronchoconstriction by inducing release of ACh from epithelial cells via OCTs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-10051150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-10084466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-10196521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-10631214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-11390648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-11682442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-12654636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-12807698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-12827517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-14560032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-14645675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-14764638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-15023864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-15278359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-15817714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-15927078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-2793705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-7531305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-7697228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-8967505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-8980957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-9037532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-9228199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16608531-9671108
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarine,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Cation Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Cation Transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Muscarinic M2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Muscarinic M3,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Slc22a2 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16608531-Acetylcholine,
pubmed-meshheading:16608531-Animals,
pubmed-meshheading:16608531-Bronchi,
pubmed-meshheading:16608531-Bronchoconstriction,
pubmed-meshheading:16608531-Mice,
pubmed-meshheading:16608531-Mice, Knockout,
pubmed-meshheading:16608531-Muscarine,
pubmed-meshheading:16608531-Organic Cation Transport Proteins,
pubmed-meshheading:16608531-Organic Cation Transporter 1,
pubmed-meshheading:16608531-Receptor, Muscarinic M2,
pubmed-meshheading:16608531-Receptor, Muscarinic M3,
pubmed-meshheading:16608531-Respiratory Mucosa,
pubmed-meshheading:16608531-Serotonin,
pubmed-meshheading:16608531-Tissue Distribution,
pubmed-meshheading:16608531-Trachea
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pubmed:year |
2006
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pubmed:articleTitle |
Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse.
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pubmed:affiliation |
Institute for Anatomy and Cell Biology, Justus-Liebig-University, 35385 Giessen, Germany. wolfgang.kummer@anatomie.med.uni-giessen.de
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pubmed:publicationType |
Journal Article,
In Vitro
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