| pubmed-article:16606368 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C0022984 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C0085103 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16606368 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16606368 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16606368 | pubmed:dateCreated | 2006-5-11 | lld:pubmed |
| pubmed-article:16606368 | pubmed:abstractText | N-acetylglucosaminyltransferase VB (GnT-VB, -IX) is a newly discovered glycosyltransferase expressed exclusively in high levels in neuronal tissue during early development. Its homolog, GnT-V, is expressed in many tissues and modulates cell-cell and cell-matrix adhesion. The ability of GnT-VB to regulate cell-matrix interactions was initially investigated using the rat pheochromocytoma PC12 neurite outgrowth model. PC12 cells stably transfected with GnT-VB consistently showed an enhanced rate of nerve growth factor (NGF)-induced neurite outgrowth on collagen and laminin substrates. Levels of TrkA receptor phosphorylation and downstream ERK activation induced by NGF were not influenced by GnT-VB expression. No significant difference was observed in the rate of neurite outgrowth when cells were cultured on non-coated culture dishes, indicating that integrin-ECM interaction is required for the stimulatory effects. Neurite outgrowth induced by manganese-dependent activation of beta1 integrin on collagen and laminin substrates, however, showed a significant increase in neurite length for the PC12/GnT-VB cells, compared with control cells, suggesting that the enhancement is most likely mediated by alteration of beta1 integrin-ECM interaction by GnT-VB. These results demonstrate that GnT-VB expression can modulate the rate of neurite outgrowth by affecting beta1 integrin-ECM interaction. | lld:pubmed |
| pubmed-article:16606368 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16606368 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16606368 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16606368 | pubmed:month | May | lld:pubmed |
| pubmed-article:16606368 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:CableM KMK | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:AbbottKarenK | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:Alvarez-Manil... | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:PierceMichael... | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:GuoHua-BeiHB | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:LeeIntaekI | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:KamarMariaM | lld:pubmed |
| pubmed-article:16606368 | pubmed:author | pubmed-author:TroupeKarolyn... | lld:pubmed |
| pubmed-article:16606368 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16606368 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:16606368 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16606368 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16606368 | pubmed:pagination | 947-56 | lld:pubmed |
| pubmed-article:16606368 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16606368 | pubmed:meshHeading | pubmed-meshheading:16606368... | lld:pubmed |
| pubmed-article:16606368 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16606368 | pubmed:articleTitle | N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen. | lld:pubmed |
| pubmed-article:16606368 | pubmed:affiliation | The Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, the University of Georgia, Athens, Georgia 30602-4712, USA. | lld:pubmed |
| pubmed-article:16606368 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16606368 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:146664 | entrezgene:pubmed | pubmed-article:16606368 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16606368 | lld:entrezgene |
