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pubmed:abstractText |
The aim of the study was to define the minimal effective dose (MED) of granulocyte colony-stimulating factor (G-CSF) among five daily doses following chemotherapy for peripheral blood stem cell (PBSC) collection. Twenty-five patients were included in this double-blind dose-finding phase II study conducted according to a two-stage Bayesian design. The estimated probabilities of success for PBSC collection for the G-CSF doses of 50, 75, 100, 125 and 150 microg/m2/day were 84%, 87.7%, 91%, 93.9 and 96.4%, respectively. Low G-CSF doses may be used with a similar probability of success as conventional doses and could allow significant savings.
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pubmed:affiliation |
Service d'Hématologie Adultes, Centre d'Investigation Clinique Hôpital Necker, Direction de la Recherche Clinique, AP-HP, Paris, France. francois.lefrere@nck.aphp.fr
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