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pubmed:abstractText |
During the last two decades progress in the genetics of aging in invertebrate models such as C. elegans and D. melanogaster has clearly demonstrated the existence of regulatory pathways that control the rate of aging in these organisms, such as the insulin-like pathway, the Jun kinase pathway and the Sir2 deacetylase pathway. Moreover, it was rapidly shown that some of these pathways are conserved from yeast to humans. In parallel to genetic studies, genomic expression approaches have given us significant information on the gene expression modifications that occur during aging either in wild type or long-lived mutant animals. But most of the genomic studies of invertebrate models have been performed so far on whole animals, while several recent studies in mammals have shown that the effects of aging are tissue specific.
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pubmed:affiliation |
Biologie du Développement, UMR7009 CNRS/UPMC, Observatoire Océanologique, Quai de la Darse, 06234 Villefranche-sur-MerCedex, France. fabrice.girardot@obs.vlfr.fr
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