|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2006-5-9
|
|
pubmed:abstractText |
We have previously shown that ML-7, which inhibits myosin light chain kinase (MLCK), induces apoptosis in transformed and non-transformed cells. We have extended these studies and found that ML-7 stimulates the ability of etoposide to induce apoptosis in Mm5MT mouse mammary adenocarcinoma cells and Mat-Ly-Lu rat prostate cancer cells in vitro. ML-7 was also found to have a chemopreventive effect using an in vitro mouse mammary organ culture model. In vivo experiments demonstrated that ML-7 retards the growth of mammary tumours in mice and prostate tumours in rats. Moreover, ML-7 significantly stimulates the ability of etoposide to prevent the growth of established mammary tumours in mice and prostate tumours in rats. These results provide evidence for the efficacy of ML-7 as an adjuvant to etoposide in these models and warrants further development.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0959-8049
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
42
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
948-57
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16574402-Adenocarcinoma,
pubmed-meshheading:16574402-Animals,
pubmed-meshheading:16574402-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:16574402-Apoptosis,
pubmed-meshheading:16574402-Azepines,
pubmed-meshheading:16574402-Cell Division,
pubmed-meshheading:16574402-Chemotherapy, Adjuvant,
pubmed-meshheading:16574402-Etoposide,
pubmed-meshheading:16574402-Humans,
pubmed-meshheading:16574402-Male,
pubmed-meshheading:16574402-Mammary Neoplasms, Experimental,
pubmed-meshheading:16574402-Mice,
pubmed-meshheading:16574402-Mice, Inbred BALB C,
pubmed-meshheading:16574402-Myosin-Light-Chain Kinase,
pubmed-meshheading:16574402-Naphthalenes,
pubmed-meshheading:16574402-Prostatic Neoplasms,
pubmed-meshheading:16574402-Random Allocation,
pubmed-meshheading:16574402-Rats
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells.
|
|
pubmed:affiliation |
Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 835 South Wolcott Ave, Chicago, IL 60612-7342, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
