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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-3-27
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pubmed:abstractText |
How stem cells generate both differentiating and self-renewing daughter cells is unclear. Here, we show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell. Like Prospero, Brat binds and cosegregates with the adaptor protein Miranda. In larval neuroblasts, both Brat and Prospero are required to inhibit self-renewal in one of the two daughter cells. While Prospero regulates cell-cycle gene transcription, Brat acts as a posttranscriptional inhibitor of dMyc. In brat or prospero mutants, both daughter cells grow and behave like neuroblasts leading to the formation of larval brain tumors. Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mira protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/brat protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/pros protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1241-53
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pubmed:dateRevised |
2008-10-16
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pubmed:meshHeading |
pubmed-meshheading:16564014-Animals,
pubmed-meshheading:16564014-Brain,
pubmed-meshheading:16564014-Cell Cycle Proteins,
pubmed-meshheading:16564014-Cell Division,
pubmed-meshheading:16564014-Cell Nucleus,
pubmed-meshheading:16564014-DNA-Binding Proteins,
pubmed-meshheading:16564014-Drosophila,
pubmed-meshheading:16564014-Drosophila Proteins,
pubmed-meshheading:16564014-Gene Expression Regulation,
pubmed-meshheading:16564014-Genes, Tumor Suppressor,
pubmed-meshheading:16564014-Genes, myc,
pubmed-meshheading:16564014-Humans,
pubmed-meshheading:16564014-Larva,
pubmed-meshheading:16564014-Mutation,
pubmed-meshheading:16564014-Neoplasms,
pubmed-meshheading:16564014-Nerve Tissue Proteins,
pubmed-meshheading:16564014-Neurons,
pubmed-meshheading:16564014-Nuclear Proteins,
pubmed-meshheading:16564014-Stem Cells,
pubmed-meshheading:16564014-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.
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pubmed:affiliation |
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Dr Bohr Gasse 3-5, 1030 Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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