Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1991-11-14
pubmed:abstractText
Translation of poliovirus RNA is initiated by cap-independent internal entry of ribosomes into the 5' nontranslated region. This process is dependent on elements within the 5' nontranslated region (the internal ribosomal entry site) and may involve novel translation factors. Systematic mutation of a conserved oligopyrimidine tract has revealed a cis-acting element that is essential for translation in vitro. The function of this element is related to its position relative to other cis-acting domains. This element is part of a more complex structure that interacts with several cellular factors, but changes in protein binding after mutation of this element were not detected in a UV cross-linking assay. A 57-kDa protein from the ribosomal salt wash fraction of HeLa cells was identified that binds upstream of the oligopyrimidine tract. Translation of poliovirus mRNA in vitro was strongly and specifically inhibited by competition with the p57-binding domain (nucleotides 260 to 488) of the 5' nontranslated region of encephalomyocarditis virus, indicating a probable role for p57 in poliovirus translation. p57 is likely to be identical to the ribosome-associated factor that binds to and is necessary for the function of the internal ribosomal entry site of encephalomyocarditis virus RNA.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2077688, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-208073, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2155504, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2155820, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2157900, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-215997, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2161866, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2165605, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2168111, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2168956, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2169384, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2169432, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2170027, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2174810, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2175364, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2194110, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-224589, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2254747, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2538648, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2539524, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2547075, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2548013, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2548167, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2550319, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2552008, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2554308, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2555560, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2558011, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2695162, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2717400, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2823500, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2825586, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2835660, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2836606, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2839690, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2839722, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2839775, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2845653, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2845654, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2846865, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-2982496, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3000069, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3002037, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3010307, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3033275, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3033601, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3035560, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3035905, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3238751, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3313277, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3458245, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3548774, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3684574, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-3881765, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-4091818, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-4686199, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6202874, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6260985, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6284987, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6316275, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6323749, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6324136, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6740945, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6864790, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-6954488, http://linkedlifedata.com/resource/pubmed/commentcorrection/1656091-7060125
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
More...