| pubmed-article:16547766 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0039005 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0027686 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0264694 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0533670 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C0035124 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C1301676 | lld:lifeskim |
| pubmed-article:16547766 | lifeskim:mentions | umls-concept:C1272745 | lld:lifeskim |
| pubmed-article:16547766 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16547766 | pubmed:dateCreated | 2006-7-5 | lld:pubmed |
| pubmed-article:16547766 | pubmed:abstractText | This study investigates the long-term angiogenic effects of ANG-1 and VEGF in a swine chronic myocardial ischemia model. Four-weeks after gradual occlusion of the left circumflex coronary artery by ameroid constrictor, animals were injected with recombinant adenoviral vectors carrying either human ANG-1 (n=9), human VEGF(165) (n=10) or empty vector (n=7) into the left ventricle free wall supplied by the constricted artery. Left ventricular perfusion in animals that received AdANG-1 (3.25+/-0.16 ml/min/g, p<0.05) recovered robustly 4 weeks after gene transfer while ischemia persisted in the AdVEGF (1.09+/-0.13 ml/min/g) and empty vector (1.20+/-0.03 ml/min/g) groups. Microvascular densities in the left ventricles of animals that received AdANG-1 (19.61+/-1.76/0.572 mm(2) myocardial tissue, p<0.05) and AdVEGF (18.17+/-1.43/0.572 mm(2) myocardial tissue, p<0.05) were significantly higher than animals that received empty vector (13.53+/-0.92/0.572 mm(2) myocardial tissue) 12 weeks after gene transfer. ANG-1, but not VEGF, contributed to enhanced regional perfusion by increasing arteriolar density (1.9+/-0.4/0.572 mm(2) myocardial tissue vs. 0.7+/-0.2/0.572 mm(2) myocardial tissue, p<0.05) of large-sized (50-100 microm) arterioles. These data demonstrate that gene transfer of ANG-1 and VEGF enhances angiogenesis, but ANG-1 promotes sustained improvement of ventricular perfusion that expedites recovery of ischemic myocardium via arteriogenesis. | lld:pubmed |
| pubmed-article:16547766 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16547766 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16547766 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16547766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16547766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16547766 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16547766 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16547766 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16547766 | pubmed:issn | 1021-7770 | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:FuY PYP | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:ZhangLiL | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:GeRuowenR | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:LiShiqiS | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:ShimWinston... | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:BapnaAkanksha... | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:LimYean... | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:WongPhilipP | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:SimEugene K... | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:OngHwee... | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:SongIn-ChinIC | lld:pubmed |
| pubmed-article:16547766 | pubmed:author | pubmed-author:ChuahSeng... | lld:pubmed |
| pubmed-article:16547766 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16547766 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16547766 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16547766 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16547766 | pubmed:pagination | 579-91 | lld:pubmed |
| pubmed-article:16547766 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16547766 | pubmed:meshHeading | pubmed-meshheading:16547766... | lld:pubmed |
| pubmed-article:16547766 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16547766 | pubmed:articleTitle | Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. | lld:pubmed |
| pubmed-article:16547766 | pubmed:affiliation | Research and Development Unit, National Heart Center, 17 Third Hospital Avenue, Singapore 168752, Singapore. winston_shim_sn@nhc.com.sg | lld:pubmed |
| pubmed-article:16547766 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16547766 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16547766 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:284 | entrezgene:pubmed | pubmed-article:16547766 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16547766 | lld:pubmed |
