Source:http://linkedlifedata.com/resource/pubmed/id/16547766
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2006-7-5
|
| pubmed:abstractText |
This study investigates the long-term angiogenic effects of ANG-1 and VEGF in a swine chronic myocardial ischemia model. Four-weeks after gradual occlusion of the left circumflex coronary artery by ameroid constrictor, animals were injected with recombinant adenoviral vectors carrying either human ANG-1 (n=9), human VEGF(165) (n=10) or empty vector (n=7) into the left ventricle free wall supplied by the constricted artery. Left ventricular perfusion in animals that received AdANG-1 (3.25+/-0.16 ml/min/g, p<0.05) recovered robustly 4 weeks after gene transfer while ischemia persisted in the AdVEGF (1.09+/-0.13 ml/min/g) and empty vector (1.20+/-0.03 ml/min/g) groups. Microvascular densities in the left ventricles of animals that received AdANG-1 (19.61+/-1.76/0.572 mm(2) myocardial tissue, p<0.05) and AdVEGF (18.17+/-1.43/0.572 mm(2) myocardial tissue, p<0.05) were significantly higher than animals that received empty vector (13.53+/-0.92/0.572 mm(2) myocardial tissue) 12 weeks after gene transfer. ANG-1, but not VEGF, contributed to enhanced regional perfusion by increasing arteriolar density (1.9+/-0.4/0.572 mm(2) myocardial tissue vs. 0.7+/-0.2/0.572 mm(2) myocardial tissue, p<0.05) of large-sized (50-100 microm) arterioles. These data demonstrate that gene transfer of ANG-1 and VEGF enhances angiogenesis, but ANG-1 promotes sustained improvement of ventricular perfusion that expedites recovery of ischemic myocardium via arteriogenesis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
1021-7770
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| pubmed:author |
pubmed-author:BapnaAkankshaA,
pubmed-author:ChuahSeng ChyeSC,
pubmed-author:FuY PYP,
pubmed-author:GeRuowenR,
pubmed-author:LiShiqiS,
pubmed-author:LimYean TengYT,
pubmed-author:OngHwee ChooHC,
pubmed-author:ShimWinston S NWS,
pubmed-author:SimEugene K WEK,
pubmed-author:SongIn-ChinIC,
pubmed-author:WongPhilipP,
pubmed-author:ZhangLiL
|
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
579-91
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16547766-Adenoviridae,
pubmed-meshheading:16547766-Analysis of Variance,
pubmed-meshheading:16547766-Angiopoietin-1,
pubmed-meshheading:16547766-Animals,
pubmed-meshheading:16547766-Coronary Angiography,
pubmed-meshheading:16547766-Coronary Circulation,
pubmed-meshheading:16547766-Coronary Vessels,
pubmed-meshheading:16547766-DNA Primers,
pubmed-meshheading:16547766-Gene Therapy,
pubmed-meshheading:16547766-Genetic Vectors,
pubmed-meshheading:16547766-Humans,
pubmed-meshheading:16547766-Immunohistochemistry,
pubmed-meshheading:16547766-Myocardial Ischemia,
pubmed-meshheading:16547766-Myocardial Reperfusion,
pubmed-meshheading:16547766-Neovascularization, Physiologic,
pubmed-meshheading:16547766-Regional Blood Flow,
pubmed-meshheading:16547766-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16547766-Swine,
pubmed-meshheading:16547766-Vascular Endothelial Growth Factor A
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model.
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| pubmed:affiliation |
Research and Development Unit, National Heart Center, 17 Third Hospital Avenue, Singapore 168752, Singapore. winston_shim_sn@nhc.com.sg
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|