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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0040627,
umls-concept:C0040649,
umls-concept:C0332307,
umls-concept:C0449560,
umls-concept:C0812246,
umls-concept:C1156210,
umls-concept:C1456820,
umls-concept:C1708726,
umls-concept:C2346501
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pubmed:issue |
7
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pubmed:dateCreated |
2006-3-20
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pubmed:abstractText |
The transactivator of transcription (Tat) protein is essential for efficient HIV type 1 (HIV-1) replication and is involved in the transcriptional regulation of the host immune response gene, TNF. In this study, we demonstrate that Tat proteins from representative HIV-1 subtype E isolates, but not from subtypes B or C, selectively inhibit TNF gene transcription and protein production in CD4(+) Jurkat T cells. Strikingly, we show that this repression is due to a tryptophan at residue 32 of Tat E and is secondary to interference with recruitment of the histone acetyltransferase P/CAF to the TNF promoter and with chromatin remodeling of the TNF locus. This study presents a novel mechanism by which HIV-1 manipulates a host immune response gene that is important in its own replication. Moreover, these results demonstrate a new mechanism by which the TNF gene is regulated via chromatin remodeling secondary to viral infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/p300-CBP Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/p300-CBP-associated factor,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4182-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16547255-Acetylation,
pubmed-meshheading:16547255-Amino Acid Sequence,
pubmed-meshheading:16547255-Cell Cycle Proteins,
pubmed-meshheading:16547255-Chromatin Assembly and Disassembly,
pubmed-meshheading:16547255-Gene Expression Regulation,
pubmed-meshheading:16547255-Gene Products, tat,
pubmed-meshheading:16547255-Genetic Variation,
pubmed-meshheading:16547255-HIV-1,
pubmed-meshheading:16547255-Histone Acetyltransferases,
pubmed-meshheading:16547255-Histones,
pubmed-meshheading:16547255-Humans,
pubmed-meshheading:16547255-Jurkat Cells,
pubmed-meshheading:16547255-Models, Molecular,
pubmed-meshheading:16547255-Molecular Sequence Data,
pubmed-meshheading:16547255-Promoter Regions, Genetic,
pubmed-meshheading:16547255-Protein Structure, Tertiary,
pubmed-meshheading:16547255-Trans-Activators,
pubmed-meshheading:16547255-Transcription, Genetic,
pubmed-meshheading:16547255-Transcription Factors,
pubmed-meshheading:16547255-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16547255-p300-CBP Transcription Factors,
pubmed-meshheading:16547255-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2006
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pubmed:articleTitle |
Transactivator of transcription from HIV type 1 subtype E selectively inhibits TNF gene expression via interference with chromatin remodeling of the TNF locus.
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pubmed:affiliation |
CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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