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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-3-20
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pubmed:abstractText |
Tamoxifen is the most commonly used antiestrogen for the treatment of breast cancer. Several clinical trials demonstrate that tamoxifen reduces the risk of heart disease and osteoporosis. However, the mechanism by which tamoxifen causes cardioprotection is unclear. Because increased levels of tumor necrosis factor alpha (TNFalpha) in tissue and/or plasma have been observed in virtually all forms of cardiac injury, we investigated whether tamoxifen prevents cardiac injury in a murine model of acute TNFalpha challenge. Five- to six-week-old female mice were injected (ip) with tamoxifen at 0.25 mg/kg daily for 3 or 7 days before receiving an injection of TNFalpha. Ultrastructural examination of cardiac tissues revealed remarkable protection against TNFalpha-induced mitochondrial damage in tamoxifen pretreated mice. Tamoxifen treatment significantly improved the mitochondrial respiratory function and enhanced superoxide-scavenging activity of mitochondria. These findings reveal a novel mitochondria-mediated mechanism by which tamoxifen exerts its cardiac protection effect against acute TNFalpha-induced heart injury.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cardiotonic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex I,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor Decoy...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/recombinant human tumor necrosis...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0891-5849
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1234-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16545692-Animals,
pubmed-meshheading:16545692-Cardiotonic Agents,
pubmed-meshheading:16545692-Electron Transport Complex I,
pubmed-meshheading:16545692-Female,
pubmed-meshheading:16545692-Free Radical Scavengers,
pubmed-meshheading:16545692-Heart Diseases,
pubmed-meshheading:16545692-Mice,
pubmed-meshheading:16545692-Mice, Inbred C57BL,
pubmed-meshheading:16545692-Mice, Knockout,
pubmed-meshheading:16545692-Mitochondria, Heart,
pubmed-meshheading:16545692-Myocardium,
pubmed-meshheading:16545692-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16545692-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:16545692-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:16545692-Superoxides,
pubmed-meshheading:16545692-Tamoxifen,
pubmed-meshheading:16545692-Tumor Necrosis Factor Decoy Receptors,
pubmed-meshheading:16545692-Tumor Necrosis Factor-alpha
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pubmed:year |
2006
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pubmed:articleTitle |
Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions.
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pubmed:affiliation |
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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