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rdf:type |
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lifeskim:mentions |
umls-concept:C0009368,
umls-concept:C0012472,
umls-concept:C0021853,
umls-concept:C0030685,
umls-concept:C0033268,
umls-concept:C0178485,
umls-concept:C0225360,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578
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pubmed:issue |
3
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pubmed:dateCreated |
2006-3-14
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pubmed:abstractText |
Mice lacking the pertussis toxin-sensitive G-protein subunit Gi alpha2 spontaneously develop colitis and colon cancer. In the gut, arachidonate-derived prostaglandin E2 (PGE2) modulates intestinal immune responses and epithelial restitution and is derived largely from subepithelial myofibroblasts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0998
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-65
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16534415-Animals,
pubmed-meshheading:16534415-Arachidonate 12-Lipoxygenase,
pubmed-meshheading:16534415-Base Sequence,
pubmed-meshheading:16534415-Cells, Cultured,
pubmed-meshheading:16534415-Colon,
pubmed-meshheading:16534415-Cyclooxygenase 1,
pubmed-meshheading:16534415-Cyclooxygenase 2,
pubmed-meshheading:16534415-Dinoprostone,
pubmed-meshheading:16534415-Disease Models, Animal,
pubmed-meshheading:16534415-Down-Regulation,
pubmed-meshheading:16534415-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16534415-Inflammatory Bowel Diseases,
pubmed-meshheading:16534415-Intestinal Mucosa,
pubmed-meshheading:16534415-Intestine, Small,
pubmed-meshheading:16534415-Mice,
pubmed-meshheading:16534415-Mice, Inbred Strains,
pubmed-meshheading:16534415-Molecular Sequence Data,
pubmed-meshheading:16534415-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16534415-Sensitivity and Specificity
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pubmed:year |
2006
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pubmed:articleTitle |
Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts.
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pubmed:affiliation |
Department of Pathology, University of California Irvine, Irvine, California 92697-4800, USA. redwards@uci.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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