Source:http://linkedlifedata.com/resource/pubmed/id/16526023
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-4-3
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| pubmed:abstractText |
Glutamatergic dysfunction is one of the major hypotheses for the pathogenesis of schizophrenia. The GRIA1 gene encodes for one (GluR1) of the four (GluR1-4) ionotropic AMPA receptor subunits. GRIA1 is a good candidate gene for susceptibility to schizophrenia since it maps in 5q33, a region where the presence of susceptibility loci has been suggested by independent genome-wide scans and because its expression has been found to be decreased in the brain of some schizophrenia patients. We present data from a case-control association study on the Italian population with eight polymorphisms spanning the whole GRIA1 gene. Single-locus analysis revealed a significantly different allele distribution in cases and in controls of two SNPs (rs707176, 0.41 vs. 0.31, P = 0.009; rs2963944, 0.41 vs. 0.30, P = 0.007), and one microsatellite (rs10631988, allele 9: 0.40 vs. 0.29, P = 0.004). Haplotype analysis showed an increased frequency of a specific haplotype for these markers (C09CC, 0.39 vs. 0.28, P = 0.009). Therefore our data indicate that GRIA1 may be involved in susceptibility to DSM-IV-TR schizophrenia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1552-4841
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2006 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
5
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| pubmed:volume |
141B
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
287-93
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| pubmed:dateRevised |
2008-5-21
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| pubmed:meshHeading |
pubmed-meshheading:16526023-Adult,
pubmed-meshheading:16526023-Alleles,
pubmed-meshheading:16526023-Case-Control Studies,
pubmed-meshheading:16526023-Diagnostic and Statistical Manual of Mental Disorders,
pubmed-meshheading:16526023-Female,
pubmed-meshheading:16526023-Gene Frequency,
pubmed-meshheading:16526023-Genetic Predisposition to Disease,
pubmed-meshheading:16526023-Genotype,
pubmed-meshheading:16526023-Haplotypes,
pubmed-meshheading:16526023-Humans,
pubmed-meshheading:16526023-Italy,
pubmed-meshheading:16526023-Linkage Disequilibrium,
pubmed-meshheading:16526023-Male,
pubmed-meshheading:16526023-Middle Aged,
pubmed-meshheading:16526023-Pilot Projects,
pubmed-meshheading:16526023-Polymorphism, Single Nucleotide,
pubmed-meshheading:16526023-Receptors, AMPA,
pubmed-meshheading:16526023-Schizophrenia
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample.
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| pubmed:affiliation |
Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|